WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, November 11, 2009, 29(45):14211-14222; doi:10.1523/JNEUROSCI.3948-09.2009

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Prince, J. E. A.
Right arrow Articles by Cloutier, J.-F.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prince, J. E. A.
Right arrow Articles by Cloutier, J.-F.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Robo-2 Controls the Segregation of a Portion of Basal Vomeronasal Sensory Neuron Axons to the Posterior Region of the Accessory Olfactory Bulb

Janet E. A. Prince,1,2 Jin Hyung Cho,1,2 Emilie Dumontier,1,2 William Andrews,3 Tyler Cutforth,4 Marc Tessier-Lavigne,5 John Parnavelas,3 and Jean-François Cloutier1,2

1Montreal Neurological Institute, Centre for Neuronal Survival, Montréal, Québec H3A 2B4, Canada, 2Department of Neurology and Neurosurgery, McGill University, Montréal, Québec H3A 2B4, Canada, 3Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom, 4Department of Molecular, Cell & Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064, and 5Division of Research, Genentech Inc., South San Francisco, California 94080

Correspondence should be addressed to Jean-François Cloutier, Montreal Neurological Institute, Centre for Neuronal Survival, 3801 University, Montréal, QC H3A 2B4, Canada. Email: jf.cloutier{at}mcgill.ca

The ability of sensory systems to detect and process information from the environment relies on the elaboration of precise connections between sensory neurons in the periphery and second order neurons in the CNS. In mice, the accessory olfactory system is thought to regulate a wide variety of social and sexual behaviors. The expression of the Slit receptors Robo-1 and Robo-2 in vomeronasal sensory neurons (VSNs) suggests they may direct the stereotypic targeting of their axons to the accessory olfactory bulb (AOB). Here, we have examined the roles of Robo-1 and Robo-2 in the formation of connections by VSN axons within the AOB. While Robo-1 is not necessary for the segregation of VSN axons within the anterior and posterior regions of the AOB, Robo-2 is required for the targeting of some basal VSN axons to the posterior region of the AOB but is dispensable for the fasciculation of VSN axons. Furthermore, the specific ablation of Robo-2 expression in VSNs leads to mistargeting of a portion of basal VSN axons to the anterior region of the AOB, indicating that Robo-2 expression is required on projecting VSN axons. Together, these results identify Robo-2 as a receptor that controls the targeting of basal VSN axons to the posterior AOB.

Received Aug. 12, 2009; revised Sept. 23, 2009; accepted Sept. 25, 2009.

Correspondence should be addressed to Jean-François Cloutier, Montreal Neurological Institute, Centre for Neuronal Survival, 3801 University, Montréal, QC H3A 2B4, Canada. Email: jf.cloutier{at}mcgill.ca
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2010 by Society for Neuroscience ONLINE ISSN: 1529-2401
-