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The Journal of Neuroscience, February 25, 2009, 29(8):2510-2518; doi:10.1523/JNEUROSCI.5333-08.2009

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Cellular/Molecular
L-Type Calcium Channels Govern Calcium Signaling in Migrating Newborn Neurons in the Postnatal Olfactory Bulb

Daniel P. Darcy and Jeffry S. Isaacson

Department of Neuroscience, University of California, San Diego School of Medicine, La Jolla, California 92093

Correspondence should be addressed to Jeffry S. Isaacson, Department of Neuroscience, Center for Molecular Genetics, Room 213, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0634. Email: jisaacson{at}ucsd.edu

Newborn inhibitory neurons migrate into existing neural circuitry in the olfactory bulb throughout the lifetime of adult mammals. While many factors contribute to the maturation of neural circuits, intracellular calcium is believed to play an important role in regulating cell migration and the development of neural systems. However, the factors underlying calcium signaling within newborn neurons in the postnatal olfactory bulb are not well understood. Here, we show that migrating, immature neurons in the olfactory bulb subependymal layer (SEL) undergo spontaneous and depolarization-evoked intracellular calcium transients mediated by high-voltage-activated L-type calcium channels. In contrast to migrating immature neurons in other brain regions, modulation of calcium transients in SEL cells does not alter their rate of migration.

Key words: olfactory bulb; calcium channels; migration; interneurons; development; subventricular zone

Received Nov. 5, 2008; revised Jan. 12, 2009; accepted Jan. 20, 2009.

Correspondence should be addressed to Jeffry S. Isaacson, Department of Neuroscience, Center for Molecular Genetics, Room 213, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0634. Email: jisaacson{at}ucsd.edu






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