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The Journal of Neuroscience, February 25, 2009, 29(8):2563-2568; doi:10.1523/JNEUROSCI.5036-08.2009

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Brief Communications
Augmented Hippocampal Ripple Oscillations in Mice with Reduced Fast Excitation onto Parvalbumin-Positive Cells

Attila Rácz, ^* Alexey A. Ponomarenko, ^* Elke C. Fuchs, and Hannah Monyer

Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany

Correspondence should be addressed to Hannah Monyer, Department of Clinical Neurobiology, University Hospital of Neurology, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. Email: monyer{at}urz.uni-heidelberg.de

Generation of fast network oscillations in the hippocampus relies on interneurons, but the underlying specific synaptic mechanisms are not established. The excitatory recruitment of fast-spiking interneurons during hippocampal sharp waves has been suggested to be critical for the generation of 140–200 Hz ("ripple") oscillations in the CA1 area. To directly test this, we used genetically modified mice (PV–GluR-A) with reduced AMPA receptor-mediated excitation onto parvalbumin (PV)-positive interneurons and studied hippocampal oscillations in freely moving animals. In PV–GluR-A mice, ripple-amplitude and associated rhythmic modulation of pyramidal cells and fast-spiking interneurons were increased. These changes were not accompanied by concurrent alterations of firing rates. Neither theta nor gamma oscillations displayed marked alterations in the mutant. These results provide evidence that fast excitation from pyramidal cells to PV-positive interneurons differentially influences ripple and gamma oscillations in vivo.

Key words: AMPA receptors; gamma oscillations; sharp waves; interneurons; burst discharge; synchronization

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Received Oct. 21, 2008; revised Jan. 13, 2009; accepted Jan. 30, 2009.

Correspondence should be addressed to Hannah Monyer, Department of Clinical Neurobiology, University Hospital of Neurology, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. Email: monyer{at}urz.uni-heidelberg.de

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