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The Journal of Neuroscience, February 25, 2009, 29(8):2626-2636; doi:10.1523/JNEUROSCI.4800-08.2009

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Behavioral/Systems/Cognitive
The Origin of Adaptation in the Auditory Pathway of Locusts Is Specific to Cell Type and Function

K. Jannis Hildebrandt,1 Jan Benda,2 and R. Matthias Hennig1

1Behavioural Physiology and 2Theoretical Biology, Biology Department, Humboldt-Universität zu Berlin, 10115 Berlin, Germany

Correspondence should be addressed to K. Jannis Hildebrandt, Behavioural Physiology, Biology Department, Humboldt-Universität zu Berlin, Invalidenstrasse 43, 10115 Berlin, Germany. Email: jannis.hildebrandt{at}biologie.hu-berlin.de

We investigated the origin of spike frequency adaptation within a layered sensory network: the auditory pathway of locusts. Spike frequency adaptation as observed in an individual neuron may arise because of intrinsic or presynaptic adaptation mechanisms. To separate the contribution of different mechanisms, we recorded from the same cell during acoustic and intracellular current stimulation. We studied three identified neuron types that are representative for each network layer and participate in processing auditory patterns and localizing sound sources. By comparing current and acoustic stimulation, three distinct patterns of the distribution of adaptation mechanisms within the sensory network emerged: (1) balanced influence of both intrinsic and presynaptic adaptation mechanisms in an interneuron that summates over several receptor afferents (TN1), (2) predominantly inhibiting input as the source for spike frequency adaptation in a cell that transmits both pattern representation and directional information (BSN1), (3) primarily intrinsic, spike-triggered adaptation currents within an interneuron coding exclusively for direction (AN2). The time courses of spike frequency adaptation differed significantly between the cells types. Using the adaptation time constants, we were able to predict signal transmission properties for the different cells. We conclude that the adaptation mechanisms differ greatly among interneurons within this sensory pathway and are a function of their role in information processing.

Key words: spike frequency adaptation; auditory system; invertebrate; signal transmission; adaptation mechanisms; temporal

Received Oct. 6, 2008; revised Jan. 8, 2009; accepted Jan. 15, 2009.

Correspondence should be addressed to K. Jannis Hildebrandt, Behavioural Physiology, Biology Department, Humboldt-Universität zu Berlin, Invalidenstrasse 43, 10115 Berlin, Germany. Email: jannis.hildebrandt{at}biologie.hu-berlin.de






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