 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 3, 20-30, Copyright © 1983 by Society for Neuroscience
Pathfinding by neuronal growth cones in grasshopper embryos. I. Divergent choices made by the growth cones of sibling neurons
JA Raper, M Bastiani and CS Goodman
We are interested in how the growth cones of identified neurons navigate in
the central nervous system of the grasshopper embryo. The behavior of
identified growth cones was observed as a function of developmental time by
(i) periodically removing embryos from synchronized clutches of eggs and
(ii) filling identified neurons in the central nervous system with the
fluorescent dye Lucifer Yellow. We examined the first six progeny of the
identified neuronal precursor cell, neuroblast 7-4: the Q1, Q2, G, C, Q5,
and Q6 neurons. Their growth cones extend sequentially upon the same route
across the midline of the posterior commissure of the developing ganglionic
neuropil. However, after reaching the contralateral side of the neuropil,
their growth cones diverge from each other at reproducible, cell-specific
choice points. By focusing our attention on one such choice point, at which
the growth cone of the G neuron turns anteriorly while the growth cone of
its sibling C neuron turns posteriorly, we hope to elucidate the
environmental cues which guide individual growth cones.
This article has been cited by other articles:
|
|
|
|
 
P. S. McQuillen, M. F. DeFreitas, G. Zada, and C. J. Shatz
A Novel Role for p75NTR in Subplate Growth Cone Complexity and Visual Thalamocortical Innervation
J. Neurosci.,
May 1, 2002;
22(9):
3580 - 3593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Kinrade, T Brates, G Tear, and A Hidalgo
Roundabout signalling, cell contact and trophic support confine longitudinal glia and axons in the Drosophila CNS
Development,
January 1, 2001;
128(2):
207 - 216.
[Abstract]
[PDF]
|
|
|
|
|
|
|
I. Skaliora, R. Adams, and C. Blakemore
Morphology and Growth Patterns of Developing Thalamocortical Axons
J. Neurosci.,
May 15, 2000;
20(10):
3650 - 3662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G Alvarez-Bolado, X Zhou, A. Voss, T Thomas, and P Gruss
Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus
Development,
January 3, 2000;
127(5):
1029 - 1038.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A Schmid, A Chiba, and C. Doe
Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets
Development,
January 11, 1999;
126(21):
4653 - 4689.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Holmes and J. Heilig
Fasciclin II and Beaten path modulate intercellular adhesion in Drosophila larval visual organ development
Development,
January 1, 1999;
126(2):
261 - 272.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B Wightman, R Baran, and G Garriga
Genes that guide growth cones along the C. elegans ventral nerve cord
Development,
January 7, 1997;
124(13):
2571 - 2580.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D Shepherd and S. Smith
Central projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila
Development,
January 8, 1996;
122(8):
2375 - 2384.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Seaver, E. Carpenter, and M. Bastiani
REGA-1 is a GPI-linked member of the immunoglobulin superfamily present on restricted regions of sheath cell processes in grasshopper
Development,
January 2, 1996;
122(2):
567 - 578.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G Boyan, S Therianos, J. Williams, and H Reichert
Axogenesis in the embryonic brain of the grasshopper Schistocerca gregaria: an identified cell analysis of early brain development
Development,
January 1, 1995;
121(1):
75 - 86.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G Garriga, C Desai, and H. Horvitz
Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans
Development,
January 3, 1993;
117(3):
1071 - 1087.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A Wizenmann, S Thanos, Y von Boxberg, and F Bonhoeffer
Differential reaction of crossing and non-crossing rat retinal axons on cell membrane preparations from the chiasm midline: an in vitro study
Development,
January 2, 1993;
117(2):
725 - 735.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Q. Doe
Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system
Development,
December 1, 1992;
116(4):
855 - 863.
[Abstract]
[PDF]
|
|
|
|
|
|
|
X. Cui and C. Q. Doe
ming is expressed in neuroblast sublineages and regulates gene expression in the Drosophila central nervous system
Development,
December 1, 1992;
116(4):
943 - 952.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Grenningloh, A.J. Bieber, E.J. Rehm, P.M. Snow, Z.R. Traquina, M. Hortsch, N.H. Patel, and C.S. Goodman
Molecular Genetics of Neuronal Recognition in Drosophila: Evolution and Function of Immunoglobulin Superfamily Cell Adhesion Molecules
Cold Spring Harb Symp Quant Biol,
January 1, 1990;
55(0):
327 - 340.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D.D.M. O'Leary, A.R. Bicknese, J.A. De Carlos, C.D. Heffner, S.E. Koester, L.J. Kutka, and T. Terashima
Target Selection by Cortical Axons: Alternative Mechanisms to Establish Axonal Connections in the Developing Brain
Cold Spring Harb Symp Quant Biol,
January 1, 1990;
55(0):
453 - 468.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J Dodd and T. Jessell
Axon guidance and the patterning of neuronal projections in vertebrates
Science,
November 4, 1988;
242(4879):
692 - 699.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Harrelson and C. Goodman
Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily
Science,
November 4, 1988;
242(4879):
700 - 708.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Doe, Y Hiromi, W. Gehring, and C. Goodman
Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis
Science,
January 8, 1988;
239(4836):
170 - 175.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Kuwada
Cell recognition by neuronal growth cones in a simple vertebrate embryo
Science,
August 15, 1986;
233(4765):
740 - 746.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Easter Jr, D Purves, P Rakic, and N. Spitzer
The changing view of neural specificity
Science,
November 1, 1985;
230(4725):
507 - 511.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C.Q. Doe and C.S. Goodman
Neurogenesis in Grasshopper and fushi tarazu Drosophila Embryos
Cold Spring Harb Symp Quant Biol,
January 1, 1985;
50(0):
891 - 903.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Goodman, M. Bastiani, C. Doe, S du Lac, S. Helfand, J. Kuwada, and J. Thomas
Cell recognition during neuronal development
Science,
September 21, 1984;
225(4668):
1271 - 1279.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.A. Raper, M.J. Bastiani, and C.S. Goodman
Guidance of Neuronal Growth Cones: Selective Fasciculation in the Grasshopper Embryo
Cold Spring Harb Symp Quant Biol,
January 1, 1983;
48(0):
587 - 598.
[Abstract]
[PDF]
|
|
|
|
