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Journal of Neuroscience, Vol 3, 20-30, Copyright © 1983 by Society for Neuroscience
Pathfinding by neuronal growth cones in grasshopper embryos. I. Divergent choices made by the growth cones of sibling neurons
JA Raper, M Bastiani and CS Goodman
We are interested in how the growth cones of identified neurons navigate in
the central nervous system of the grasshopper embryo. The behavior of
identified growth cones was observed as a function of developmental time by
(i) periodically removing embryos from synchronized clutches of eggs and
(ii) filling identified neurons in the central nervous system with the
fluorescent dye Lucifer Yellow. We examined the first six progeny of the
identified neuronal precursor cell, neuroblast 7-4: the Q1, Q2, G, C, Q5,
and Q6 neurons. Their growth cones extend sequentially upon the same route
across the midline of the posterior commissure of the developing ganglionic
neuropil. However, after reaching the contralateral side of the neuropil,
their growth cones diverge from each other at reproducible, cell-specific
choice points. By focusing our attention on one such choice point, at which
the growth cone of the G neuron turns anteriorly while the growth cone of
its sibling C neuron turns posteriorly, we hope to elucidate the
environmental cues which guide individual growth cones.
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