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Journal of Neuroscience, Vol 3, 31-41, Copyright © 1983 by Society for Neuroscience
Pathfinding by neuronal growth cones in grasshopper embryos. II. Selective fasciculation onto specific axonal pathways
JA Raper, M Bastiani and CS Goodman
In the previous paper (Raper, J.A., M. Bastiani, and C.S. Goodman (1983) J.
Neurosci. 3:20-30) we showed that the growth cones of two sibling neurons,
the G and C cells, follow the same route in the developing grasshopper
neuropil until they reach a stereotypic choice point. Here their growth
cones diverge from each other as G turns and extends anteriorly and C turns
and extends posteriorly. In this paper we show that the G and C growth
cones fasciculate and extend in opposite directions upon a specific bundle
of four axons. This occurs even though many other axons are within
filopodial reach of the G and C growth cones. We identified the four
neurons (the A1, A2, P1, and P2 cells) whose axons form the bundle that G
and C extend upon by filling individual axons with Lucifer Yellow and
viewing the filled cells in living embryos and by filling individual
neurons with HRP and reconstructing the axon bundle from electron
micrographs. The G neuron extends anteriorly in the bundle containing these
four axons; the C neuron extends posteriorly in the same bundle only after
several other axons have joined in. These results suggest that the growth
cones of the G and C neurons are determined to recognize and extend upon
labeled axons, leading us to propose the "labeled pathways" hypothesis.
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