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Journal of Neuroscience, Vol 3, 2365-2380, Copyright © 1983 by Society for Neuroscience
Ascending projections to the medial geniculate body of the cat: evidence for multiple, parallel auditory pathways through thalamus
MB Calford and LM Aitkin
The sources of ascending input to the medial geniculate body (MGB) of the
cat were studied using the retrograde transport of horseradish peroxidase
(HRP). HRP injections were made iontophoretically through micropipettes
which were also used to record physiological properties at the injection
sites. This technique produced small injections which appeared to be
restricted to single subnuclei. The tectothalamic projection of the
auditory system was found to consist of at least four distinct and separate
pathways. The ventral division of the MGB receives a topographical
projection from the central nucleus of the inferior colliculus (ICC) which
preserves tonotopicity and provides short latency, sharply frequency-tuned
responses. The medial part of the ICC projects to the deep dorsal nucleus,
which contains only units tuned to high frequencies. The major inputs to
the caudodorsal nucleus (DC) stem from nucleus sagulum and the pericentral
nucleus of the inferior colliculus (ICP). Units in DC and the ventrolateral
nucleus, which also receive input from ICP, have very broad tuning
properties and late, habituating responses. Injections of HRP into the
medial division (MGM) produced labeled cells scattered throughout the
external nucleus of the inferior colliculus and the ventral part of ICC.
This widespread input is reflected in the wide range of auditory responses
found in MGM. Auditory responses in the suprageniculate nucleus were poorly
defined and many units did not respond to tonal stimuli; following HRP
injections no filled cells were found in the inferior colliculus, but
labeled cells were found in the deeper layers of the superior colliculus
and in the interstitial nucleus of the brachium of the inferior colliculus.
Together with recent findings on the auditory thalamocortical projection,
these results provide evidence for multiple parallel auditory pathways
through the thalamus.
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