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Journal of Neuroscience, Vol 3, 383-388, Copyright © 1983 by Society for Neuroscience
Three-dimensional structure of dendritic spines in the rat neostriatum
CJ Wilson, PM Groves, ST Kitai and JC Linder
Dendritic spines of rat neostriatal neurons were examined by light
microscopy and high voltage stereo electron microscopy (HVEM) following
selective staining by intracellular microinjection of horseradish
peroxidase. Conventionally prepared material also was used for quantitative
analysis of dendritic spines from serial thin sections of neostriatum.
Stereo electron microscopy of semithin sections from rat neostriatum fixed
using a protocol designed to preserve cytoskeletal integrity was employed
to examine the organization of the dendritic spine cytoplasm. Light
microscopic and HVEM examination of spiny dendrites and quantitative
analysis of serial thin sections from normal material revealed no distinct
spine types but rather continuous and independent variation of spine head
diameter, stalk diameter, and stalk length. Likewise, there was no
systematic relationship between any of these spine dimensions and dendritic
diameter. Spine head membrane surface area was directly related to the area
of the synaptic junctional membrane of the spine head. In semithin
sections, the cytoplasm of the spine contained membranous saccules of spine
apparatus and a delicate cytoskeletal network composed of microfilaments
and a set of finer and more variable cytoskeletal filaments. It is proposed
that this cytoskeletal network together with the spine apparatus is
responsible for the maintenance and alteration of spine shape and in this
way controls the effectiveness of axospinous synapses.
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