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Journal of Neuroscience, Vol 3, 399-406, Copyright © 1983 by Society for Neuroscience
Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat
JI Nagy, LL Iversen, M Goedert, D Chapman and SP Hunt
The numbers of myelinated and unmyelinated fibers were counted in dorsal
roots of adult rats treated neonatally with capsaicin in doses ranging from
5 to 100 mg/kg. Substance P and somatostatin levels in the spinal cord,
dorsal roots, and sensory ganglia also were determined in control and
treated animals. Capsaicin administration lead to the loss of both small
myelinated and unmyelinated fibers from dorsal roots. However, whereas a
near total loss, up to 94%, of unmyelinated fibers was achieved after high
doses of capsaicin, the reduction of myelinated fibers, even of the
smallest caliber, did not exceed 40%. The degree of fiber loss showed a
clear dose dependency, with little detectable damage to myelinated fibers
at doses of less than 50 mg/kg and with an ED50 for damage to unmyelinated
fibers of 5 to 10 mg/kg. In all of the structures examined, particularly
the dorsal roots, a roughly parallel decrease of substance P and
somatostatin was found with capsaicin dose. The depletions of spinal cord
substance P (55%) and somatostatin (20%) produced by neonatal capsaicin
treatment were similar to those produced by dorsal rhizotomy. Capsaicin
does not appear to be specific for primary afferents containing either
substance P or somatostatin.
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