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Journal of Neuroscience, Vol 3, 1389-1413, Copyright © 1983 by Society for Neuroscience
Termination of afferent axons in macaque striate cortex
GG Blasdel and JS Lund
We used horseradish peroxidase (HRP) to orthogradely label afferent axons
in macaque striate cortex. Of the 38 axons that we recovered, nine were
recorded intracellularly before being filled with HRP. Light microscope and
computer reconstructions of filled processes reveal highly stereotyped
patterns of arborization and suggest that there are at least five discrete
populations of lateral geniculate nucleus (LGN) afferent axon: (1) those to
layer 4C beta, which have extremely circumscribed, dense terminal fields
(small branches of which occasionally intrude into 4C alpha) but which have
not been shown to project to other laminae; (2) afferents to layer 4A,
which in some cases send fine ascending collaterals into layer 2-3 and
which do not, apparently, send collaterals to other laminae; (3) afferents
to layer 1, which are fine, extend over large distances horizontally, and
send collaterals to layer 6A; (4) afferents to the lower two-thirds of
layer 4C alpha, which have few or no collaterals in layer 6; and (5)
afferents to the upper half of layer 4C alpha, which have arborizing
collaterals in layer 6B. Of the nine axons that were recorded
intracellularly, those with projections to layer 4C beta (two axons) and to
layer 1 (one axon) had color-selective properties, whereas those (six
axons) which arborized in 4C alpha all had transient, broad band and highly
contrast-sensitive receptive fields. These properties are consistent with
derivations from somata in the parvocellular and magnocellular divisions of
the LGN, respectively. Afferents to 4C alpha were found to cover
approximately 6 times as much surface area as afferents to 4C beta. The
preterminal trunks of all axons were found to follow tortuous paths through
the neuropil--paths that may derive from axon segregation during
development. The wide ranging, patchy distributions of single afferents in
4C alpha suggest that individual 4C alpha axons supply more than one ocular
dominance stripe. In one case where the terminal arborization of a 4C alpha
axon was mapped against the transneuronally determined pattern of ocular
dominance, three separate patches of terminal boutons were indeed found to
coincide with the bands of one eye.
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