QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Slaughter, M. M. Articles by Miller, R. F. Search for Related Content PubMed PubMed Citation Articles by Slaughter, M. M. Articles by Miller, R. F.

 Previous Article

Journal of Neuroscience, Vol 3, 1701-1711, Copyright © 1983 by Society for Neuroscience

ARTICLE

The role of excitatory amino acid transmitters in the mudpuppy retina: an analysis with kainic acid and N-methyl aspartate

MM Slaughter and RF Miller

A variety of glutamate and aspartate analogues were used to characterize the excitatory amino acid receptors in the mudpuppy retina. This approach revealed two general classes of receptors which were represented by the agonists kainic acid and N-methyl aspartic acid. Kainic acid was found to be a potent photoreceptor transmitter agonist on all three types of second-order neurons, and it was a powerful excitant of amacrine and ganglion cells. N-Methyl aspartate had little effect in the outer retina, but it had potent stimulatory effects on inner retinal neurons. N-Methyl aspartate antagonists selectively blocked light responses in some sustained OFF ganglion cells. These results suggest that both photoreceptors and bipolar neurons may use glutamate Or an analogue, whereas aspartate may be utilized by a class of sustained ON amacrine cells.

This article has been cited by other articles:

				S. Machida, D. Raz-Prag, R. N. Fariss, P. A. Sieving, and R. A. Bush Photopic ERG Negative Response from Amacrine Cell Signaling in RCS Rat Retinal Degeneration Invest. Ophthalmol. Vis. Sci., January 1, 2008; 49(1): 442 - 452. [Abstract] [Full Text] [PDF]

				W. Shen Repetitive Light Stimulation Inducing Glycine Receptor Plasticity in the Retinal Neurons J Neurophysiol, September 1, 2005; 94(3): 2231 - 2238. [Abstract] [Full Text] [PDF]

				S. Ueno, M. Kondo, Y. Niwa, H. Terasaki, and Y. Miyake Luminance Dependence of Neural Components that Underlies the Primate Photopic Electroretinogram Invest. Ophthalmol. Vis. Sci., March 1, 2004; 45(3): 1033 - 1040. [Abstract] [Full Text] [PDF]

				E. R. Stevens, M. Esguerra, P. M. Kim, E. A. Newman, S. H. Snyder, K. R. Zahs, and R. F. Miller D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors PNAS, May 27, 2003; 100(11): 6789 - 6794. [Abstract] [Full Text] [PDF]

				D. A. Kraaij, H. Spekreijse, and M. Kamermans The Open- and Closed-Loop Gain-Characteristics of the Cone/Horizontal Cell Synapse in Goldfish Retina J Neurophysiol, September 1, 2000; 84(3): 1256 - 1265. [Abstract] [Full Text] [PDF]

				F. Gao and S. M. Wu Characterization of Spontaneous Inhibitory Synaptic Currents in Salamander Retinal Ganglion Cells J Neurophysiol, October 1, 1998; 80(4): 1752 - 1764. [Abstract] [Full Text] [PDF]

				D. W. Crevier and M. Meister Synchronous Period-Doubling in Flicker Vision of Salamander and Man J Neurophysiol, April 1, 1998; 79(4): 1869 - 1878. [Abstract] [Full Text] [PDF]

				E. Hartveit Functional Organization of Cone Bipolar Cells in the Rat Retina J Neurophysiol, April 1, 1997; 77(4): 1716 - 1730. [Abstract] [Full Text] [PDF]

				P. D. Lukasiewicz, J. A. Wilson, and J. E. Lawrence AMPA-Preferring Receptors Mediate Excitatory Synaptic Inputs to Retinal Ganglion Cells J Neurophysiol, January 1, 1997; 77(1): 57 - 64. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help