QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kageyama, G. H. Articles by Wong-Riley, M. T. Search for Related Content PubMed PubMed Citation Articles by Kageyama, G. H. Articles by Wong-Riley, M. T.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 4, 2445-2459, Copyright © 1984 by Society for Neuroscience

ARTICLE

The histochemical localization of cytochrome oxidase in the retina and lateral geniculate nucleus of the ferret, cat, and monkey, with particular reference to retinal mosaics and ON/OFF-center visual channels

GH Kageyama and MT Wong-Riley

The histochemical localization of cytochrome oxidase within the normal retina and lateral geniculate nucleus (LGN) of cats, ferrets, and monkeys revealed that distinct layers, types of cells, and portions of neurons are more intensely stained than others. The dark staining of photoreceptor inner segments and cone pedicles and the light staining of photoreceptor outer segments, somata, and rod spherules demonstrates that different segments of the same cell may have disparate but distinct levels of oxidative enzyme activity. In tangential sections of retina, regular mosaic arrays were evident for each of several darkly reactive retinal components, such as cone inner segments, cone pedicles, and horizontal cells. In the cat and ferret, regular mosaic arrays were also formed by metabolically distinguishable populations of ganglion cells. Ia and IIa ganglion cells (OFF-; Nelson, R., E. V. Famiglietti, Jr., and H. Kolb (1978) J. Neurophysiol. 41: 472-483) were more darkly reactive than the other classes. The darker staining of sublamina a of the inner plexiform layer (OFF-; Famiglietti, E. V., Jr., and H. Kolb (1976) Science 194: 193-195) in the cat and ferret retina, as well as sublamina A' and A1' of the ferret LGN (OFF-; Stryker, M.P., and K.R. Zahs (1983a) J. Neurosci. 3: 1943-1951) suggest that, under typical rearing conditions, the OFF-channels may be metabolically more active than the ON-channels in these species. In Macaca and Saimiri, darker staining was observed in sublamina b of the inner plexiform layer (ON-; Famiglietti, E.V., Jr., and H. Kolb (1976) Science 194: 193-195) and laminae 1, 2, and 6 of the LGN, implying that, under similar rearing conditions, a different pattern is observed. The dark staining of many large retinal ganglion cells, as well as most of the larger LGN neurons (presumed Y/Y-like), in all species studied is evidence that the Y/Y-like pathway is also highly active.

This article has been cited by other articles:

				Y. Xu, N. K. Dhingra, R. G. Smith, and P. Sterling Sluggish and Brisk Ganglion Cells Detect Contrast With Similar Sensitivity J Neurophysiol, May 1, 2005; 93(5): 2388 - 2395. [Abstract] [Full Text] [PDF]

				V. Porciatti, N. Sorokac, and W. Buchser Habituation of Retinal Ganglion Cell Activity in Response to Steady State Pattern Visual Stimuli in Normal Subjects Invest. Ophthalmol. Vis. Sci., April 1, 2005; 46(4): 1296 - 1302. [Abstract] [Full Text] [PDF]

				N. D. Wangsa-Wirawan and R. A. Linsenmeier Retinal Oxygen: Fundamental and Clinical Aspects Arch Ophthalmol, April 1, 2003; 121(4): 547 - 557. [Abstract] [Full Text] [PDF]

				E. A. Bristow, P. G. Griffiths, R. M. Andrews, M. A. Johnson, and D. M. Turnbull The Distribution of Mitochondrial Activity in Relation to Optic Nerve Structure Arch Ophthalmol, June 1, 2002; 120(6): 791 - 796. [Abstract] [Full Text] [PDF]

				P Y W Man, D M Turnbull, and P F Chinnery Leber hereditary optic neuropathy J. Med. Genet., March 1, 2002; 39(3): 162 - 169. [Abstract] [Full Text] [PDF]

				M. T. Seme, P. Summerfelt, J. Neitz, J. T. Eells, and M. M. Henry Differential Recovery of Retinal Function after Mitochondrial Inhibition by Methanol Intoxication Invest. Ophthalmol. Vis. Sci., March 1, 2001; 42(3): 834 - 841. [Abstract] [Full Text]

				C. Gargini, M. S. Belfiore, S. Bisti, L. Cervetto, K. Valter, and J. Stone The Impact of Basic Fibroblast Growth Factor on Photoreceptor Function and Morphology Invest. Ophthalmol. Vis. Sci., August 1, 1999; 40(9): 2088 - 2099. [Abstract] [Full Text] [PDF]

				M. T. Seme, P. Summerfelt, M. M. Henry, J. Neitz, and J. T. Eells Formate-Induced Inhibition of Photoreceptor Function in Methanol Intoxication J. Pharmacol. Exp. Ther., April 1, 1999; 289(1): 361 - 370. [Abstract] [Full Text]

				R. M Andrews, P. G Griffiths, M. A Johnson, and D. M Turnbull Histochemical localisation of mitochondrial enzyme activity in human optic nerve and retina Br. J. Ophthalmol., February 1, 1999; 83(2): 231 - 235. [Abstract] [Full Text]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help