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Journal of Neuroscience, Vol 4, 2590-2603, Copyright © 1984 by Society for Neuroscience
Different populations of GABAergic neurons in the visual cortex and hippocampus of cat contain somatostatin- or cholecystokinin- immunoreactive material
P Somogyi, AJ Hodgson, AD Smith, MG Nunzi, A Gorio and JY Wu
The coexistence of gamma-aminobutyric acid (GABA), glutamate decarboxylase
(GAD), and cholecystokinin (CCK)- or somatostatin- immunoreactive material
in the same neurons was studied in the hippocampus and visual cortex of the
cat. One-micrometer-thick serial sections of the same neuron were reacted
to reveal different antigens by the unlabeled antibody enzyme method. All
CCK- and somatostatin- immunoreactive neurons in the cortex and all
CCK-immunoreactive and the majority of somatostatin-immunoreactive neurons
in the hippocampus that could be examined in serial sections were also
immunoreactive for GABA. In neurons that were immunoreactive for GAD it was
often possible to demonstrate immunoreactivity for one of the peptides as
well as for GABA. GABA-immunoreactive neurons, as revealed by an antiserum
to GABA, were present in all layers of the cortex and hippocampus, and
their shape, size, and distribution were similar to GAD-immunoreactive
neurons. All GAD-immunoreactive neurons were also positive for GABA, but
the latter staining revealed additional neurons. CCK/GABA- and
somatostatin/GABA-immunoreactive neurons were present mainly in layers II
and upper III and in layers V and VI in the visual cortex. CCK/GABA-
immunoreactive neurons were most frequently present in the strata oriens,
pyramidale, and moleculare of the hippocampus and in the polymorph cell
layer of the dentate gyrus. Somatostatin/GABA- immunoreactive neurons were
localized mainly in the stratum oriens and in the hilus of the fascia
dentata. The two peptides could not be found in the same neuron. The
majority of neurons that were GABA immunoreactive did not stain for either
peptide. The presence of CCK- and somatostatin-immunoreactive material in
GABAergic cortical neurons raises the possibility that neuroactive peptides
affect GABAergic neurotransmission.
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