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Journal of Neuroscience, Vol 4, 2811-2822, Copyright © 1984 by Society for Neuroscience
Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response
DA McCormick and RF Thompson
Neuronal activity was recorded from regions of the cerebellar cortex and
dentate-interpositus nuclei during learning and/or performance of a
classically conditioned nictitating membrane (NM-a third eyelid)/eyeblink
response in the rabbit. It was found that neurons located within restricted
portions of the ansiform lobule and anterior lobe cortical regions and of
the dentate-interpositus nuclei respond in relation to the performance of
the learned eyeblink response. Furthermore, chronic recordings from the
dentate-interpositus nuclei revealed that these responses develop in close
relation to the learning of the conditioned eyeblink response. Stimulation
of the dentate- interpositus nuclei through the recording electrodes in
some cases yielded eyelid closure and NM extension in both trained and
untrained animals. Lesion of the axons of the dentate-interpositus nuclei
(superior cerebellar peduncle), a manipulation which is known to abolish
the learned eyeblink response, abolished the stimulation effect. We have
previously reported that lesions of the dentate- interpositus nuclei cause
abolition of the learned eyeblink response. In the present study, we report
that lesions of the regions of cerebellar cortex projecting to the
dentate-interpositus nuclei do not permanently abolish the conditioned
response, although the amplitude- time course of the learned response could
be affected. These results, together with results of other studies,
demonstrate that the medial dentate and/or lateral interpositus nuclei are
active during learning and performance of the conditioned eyeblink
response, are capable of producing this learned response, and are essential
for the learning and retention of the conditioned eyeblink response.
Therefore, the medial dentate and/or lateral interpositus nuclei are a part
of the essential neuronal circuit involved in the learning and production
of the classically conditioned eyeblink response in the rabbit.
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