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Journal of Neuroscience, Vol 4, 2986-2992, Copyright © 1984 by Society for Neuroscience
The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in rat dorsal root ganglia
HK Yip, KM Rich, PA Lampe and EM Johnson Jr
Nerve growth factor (NGF) is known to be essential for survival and
maintenance of sympathetic ganglia and of embryonic sensory ganglia of
neural crest origin. The present study examined the physiological and
pharmacological roles of NGF in the postnatal development of sensory
neurons in the dorsal root ganglion (DRG). In contrast to what is generally
stated in the literature, administration of NGF antiserum to newborn rats
for a period of 7 days resulted in a significant (approximately 20%)
reduction of neuronal number in the lumbar DRG. Size spectrum analysis of
surviving neurons revealed a shift toward larger sizes, presumably due to a
preferential loss of small cells. The number of neurons in the L5 DRG was
studied at various times after unilateral sciatic nerve crush in 1-day-old
rats. Axotomy resulted in a substantial loss (40 to 50%) of neurons in the
immature DRG. Administration of NGF antiserum to animals with axotomized
DRG did not increase cell death when compared with the axotomized controls.
However, the number of neurons in the antiserum-treated ganglia decreased
by the same percentage (20%) when compared with the control serum-treated
ganglia before and after axotomy. Treatment with NGF initially prevented
the loss of neurons in the axotomized DRG. However, some neurons died
during the first week despite continued NGF administration; and, subsequent
to NGF withdrawal, neuronal number decreased to the same level as in
control animals. Thus, removal of exogenous NGF resulted in the death of
the sensory neurons which had been maintained.(ABSTRACT TRUNCATED AT 250
WORDS)
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