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Journal of Neuroscience, Vol 4, 3021-3033, Copyright © 1984 by Society for Neuroscience
Patterns of synaptic input to layer 4 of cat striate cortex
BA McGuire, JP Hornung, CD Gilbert and TN Wiesel
Although cells in layer 4 of cat striate cortex represent the first stage
in the cortical processing of visual information, they have considerably
more complicated receptive field properties than the afferents to the layer
from the lateral geniculate nucleus. In considering how these properties
are generated, we have focused on the intrinsic cortical circuitry, and
particularly on the projection to layer 4 from layer 6. Layer 6 pyramidal
cells were injected with horseradish peroxidase and examined at the light
and electron microscopic level. The labeled axon terminals were found to
form asymmetric synapses and to show a strong preference for contacting
dendritic shafts. Serial reconstruction of dendrites postsynaptic to
labeled layer 6 cell axon terminals showed that a large proportion of the
postsynaptic dendrites belonged to smooth and sparsely spiny stellate
cells, suggesting a selective innervation of these cell types. In contrast,
the geniculate projection to layer 4 made synapses primarily with dendritic
spines and, as a result, the large majority of terminals ended on spiny
cells. Since smooth and sparsely spiny stellate cells are thought to
mediate inhibition within the cortex, we suggest that one effect of the
layer 6 to layer 4 projection could be to contribute to inhibitory features
of the receptive fields of layer 4 cells.
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