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Journal of Neuroscience, Vol 4, 732-740, Copyright © 1984 by Society for Neuroscience
Effects of iontophoretically released amino acids and amines on primate spinothalamic tract cells
WS Willcockson, JM Chung, Y Hori, KH Lee and WD Willis
The effects of glutamate (Glu), gamma-aminobutyric acid (GABA), glycine
(Gly), serotonin (5-HT), norepinephrine (NE), dopamine (DA), and
acetylcholine (ACh) were examined in this study by iontophoretic
application onto primate spinothalamic tract (STT) neurons identified
antidromically by stimulation in the contralateral thalamus. Drugs were
tested for effects on background activity, Glu-induced firing, and activity
evoked by pinching of the skin. Whereas Glu excited STT cells and was thus
used for tests of the other compounds, the amino acids GABA and Gly
inhibited Glu- and pinch-induced activity in all STT cells examined. STT
cells were also inhibited by 5-HT, NE, and DA. Only two cases of excitation
by 5-HT were seen (of 58 cells tested). ACh also had inhibitory actions on
STT cells, although 3 of 21 cells exhibited some enhancement of activity.
The effects of these compounds on identified STT cells resemble previous
demonstrations of the effects of these drugs on dorsal horn interneurons.
The results suggest that GABA, Gly, 5-HT, NE, and DA may be inhibitory
neurotransmitters on nociceptive STT cells.
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