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Journal of Neuroscience, Vol 4, 860-867, Copyright © 1984 by Society for Neuroscience
Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro
AL Mueller, JS Taube and PA Schwartzkroin
The postnatal development of IPSPs and response to locally applied GABA
were examined using intracellular recording techniques in region CA1 of
rabbit hippocampal slices maintained in vitro. Pyramidal neurons in slices
from mature rabbits demonstrated an EPSP-IPSP sequence following
stimulation of stratum radiatum. In these same slices, pressure application
of GABA into stratum pyramidale and stratum radiatum produced membrane
hyperpolarization and depolarization, respectively. Pyramidal neurons in
slices from immature rabbits (age 6 to 10 days) responded differently.
Stimulation of stratum radiatum produced a prolonged depolarizing
postsynaptic potential; few IPSPs were observed. Ejection of GABA into
either stratum pyramidale or stratum radiatum evoked a depolarizing
response. The GABA agonist, 4,5,6,7- tetrahydroisoxazolo [5,4-c]
pyridine-3-ol (THIP), which has been reported to activate "hyperpolarizing"
GABA receptors selectively, primarily produced membrane hyperpolarization
when applied to the somata of mature neurons, but it evoked a
depolarization when applied to immature neurons. Bicuculline, a GABA
antagonist which may have a preferential selectivity for "depolarizing"
GABA receptors, was somewhat more efficacious (at 50 microM concentration)
at antagonizing GABA-evoked depolarization in immature cells than
GABA-evoked hyperpolarization in mature cells. This same concentration of
bicuculline partially antagonized IPSPs in mature cells, and it markedly
potentiated depolarizing PSPs in immature cells. Taken together, these
results suggest that the late development of synaptic inhibition in rabbit
hippocampus is due, at least in part, to an immaturity in the GABAergic
system.
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