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Journal of Neuroscience, Vol 4, 989-1000, Copyright © 1984 by Society for Neuroscience
Cell determination and differentiation of identified serotonin- immunoreactive neurons in the grasshopper embryo
PH Taghert and CS Goodman
We have begun to investigate the factors that underlie neurotransmitter
determination in the central nervous system of the grasshopper embryo. The
most prominent serotonin-immunoreactive neurons in the segmental ganglia
are three clonally related interneurons, cells S1, S2, and S3. S1 and S2
are sibling neurons and are the first two born in the family of neurons
that is produced by neuroblast 7-3; cell S3 derives from one of the
second-born pair in the same family. S1 is serotonin- immunoreactive in all
thoracic and abdominal segments, S2 in all but two segments (T3 and A1),
and S3 in only the prothorax (T1). These segment-specific differences are
not due to differential cell death but rather can be ascribed to
biochemical differences between lineally homologous neurons. Furthermore,
these homologous neurons also display interesting segment-specific
differences in their morphology. Laser ablation of neuroblast 7-3 before it
begins its series of programmed cell divisions results in the absence of
its normal serotonin- immunoreactive neuronal progeny when screened at
mature stages. These experiments support the hypothesis that transmitter
determination is at least in part regulated by cell lineage in the
grasshopper embryo and that some clonally related neurons appear to share a
common transmitter determination by virtue of their common lineage. The
results further suggest that cell lineage regulation of transmitter
determination may vary according to segment or may be modified by as yet
unidentified segment-specific factors.
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