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Journal of Neuroscience, Vol 4, 2025-2042, Copyright © 1984 by Society for Neuroscience
Antibodies against filamentous components in discrete cell types of the mouse retina
UC Drager, DL Edwards and CJ Barnstable
Three monoclonal antibodies have been raised against the ganglion cell
layer of the adult mouse retina. The first antibody, R3, labeled optic
axons in the inner retina, and with colchicine pretreatment somata and
dendrites of large ganglion cells could be seen. A small number of other
processes, including fibers projecting to the retina from elsewhere
(efferent fibers), were also labeled in the inner retina. In the outer
plexiform layer R3 stained the axonless class of horizontal cells. R3
recognized a 185,000- to 200,000-dalton polypeptide which is most probably
the heaviest of the neurofilament subunits. Antibodies R4 and R5 labeled
filamentous components mainly in glia and cells of mesenchymal origin. The
antigens appeared in most but not quite all locations morphologically
closely related to the intermediate filament protein vimentin. In the
retina both antibodies labeled strongly the regularly spaced Muller glia.
The astroglia of the optic fiber layer was stained with R5 but not R4.
Although the two antigens were in general not expressed in neurons, they
were both present in axonless horizontal cells in the outer plexiform
layer, coexisting with neurofilaments in this neuron.
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