 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 4, 2311-2328, Copyright © 1984 by Society for Neuroscience
Pathfinding by neuronal growth cones in grasshopper embryos. III. Selective affinity of the G growth cone for the P cells within the A/P fascicle
MJ Bastiani, JA Raper and CS Goodman
The growth cone of the G neuron selectively fasciculates upon specific axon
bundles in a stereotypic sequence as it navigates through the developing
central nervous system of the grasshopper embryo. It turns and extends
anteriorly in the contralateral neuropil of the second thoracic ganglion at
a specific choice point where it fasciculates with the A/P axon bundle
which contains the axons of the A1, A2, P1, and P2 neurons. We previously
hypothesized (Raper, J. A., M. J. Bastiani, and C. S. Goodman (1983) J.
Neurosci. 3: 20-41) that this fascicle, or subsets of axons within it, were
specifically labeled and that the G neuron was determined to follow this
labeled pathway. Here we report on an ultrastructural analysis of the
interactions between the G growth cone and its filopodia with the cells of
the A/P fascicle at the choice point. As G reaches its choice point, its
filopodia are in more frequent contact with the A/P fascicle in comparison
to the other longitudinal axon fascicles. Within the A/P fascicle, the tip
of G's growth cone is found to be closely associated with the P and not the
A axons. Furthermore, before the G growth cone climbs onto the A/P
fascicle, its filopodia show a selective affinity for the P axons as
compared to the A axons. Another specific interaction involves selective
filopodial insertions; only filopodia from the P cells were found to insert
into the G growth cone and induce coated pits and vesicles. These findings
suggest that G is able to distinguish the A/P fascicle from other axon
bundles and, moreover, is able to distinguish the P axons from the A axons.
The companion paper (Raper, J. A., M. J. Bastiani, and C. S. Goodman (1984)
J. Neurosci. 4: 2329-2345) presents experimental results based on specific
axon ablations that further support this hypothesis.
This article has been cited by other articles:
|
|
|
|
 
M. A. Wolman, A. M. Regnery, T. Becker, C. G. Becker, and M. C. Halloran
Semaphorin3D Regulates Axon Axon Interactions by Modulating Levels of L1 Cell Adhesion Molecule
J. Neurosci.,
September 5, 2007;
27(36):
9653 - 9663.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bak and S. E. Fraser
Axon fasciculation and differences in midline kinetics between pioneer and follower axons within commissural fascicles
Development,
October 15, 2003;
130(20):
4999 - 5008.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Kinrade, T Brates, G Tear, and A Hidalgo
Roundabout signalling, cell contact and trophic support confine longitudinal glia and axons in the Drosophila CNS
Development,
January 1, 2001;
128(2):
207 - 216.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Holmes and J. Heilig
Fasciclin II and Beaten path modulate intercellular adhesion in Drosophila larval visual organ development
Development,
January 1, 1999;
126(2):
261 - 272.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. Menon and K Zinn
Tyrosine kinase inhibition produces specific alterations in axon guidance in the grasshopper embryo
Development,
January 10, 1998;
125(20):
4121 - 4131.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. M. Bolin, T. McNeil, L. A. Lucian, B. DeVaux, K. Franz-Bacon, D. M. Gorman, S. Zurawski, R. Murray, and T. K. McClanahan
HNMP-1: A Novel Hematopoietic and Neural Membrane Protein Differentially Regulated in Neural Development and Injury
J. Neurosci.,
July 15, 1997;
17(14):
5493 - 5502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Harrelson and C. Goodman
Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily
Science,
November 4, 1988;
242(4879):
700 - 708.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Goodman, M. Bastiani, C. Doe, S du Lac, S. Helfand, J. Kuwada, and J. Thomas
Cell recognition during neuronal development
Science,
September 21, 1984;
225(4668):
1271 - 1279.
[Abstract]
[PDF]
|
|
|
|
