 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 5, 3178-3183, Copyright © 1985 by Society for Neuroscience
125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells
KA Yagaloff and PR Hartig
125I-Lysergic acid diethylamide (125I-LSD) binds with high affinity to
serotonergic sites on rat choroid plexus. These sites were localized to
choroid plexus epithelial cells by use of a novel high resolution stripping
film technique for light microscopic autoradiography. In membrane
preparations from rat choroid plexus, the serotonergic site density was
3100 fmol/mg of protein, which is 10-fold higher than the density of any
other serotonergic site in brain homogenates. The choroid plexus site
exhibits a novel pharmacology that does not match the properties of
5-hydroxytryptamine-1a (5-HT1a), 5-HT1b, or 5-HT2 serotonergic sites.
125I-LSD binding to the choroid plexus site is potently inhibited by
mianserin, serotonin, and (+)-LSD. Other serotonergic, dopaminergic, and
adrenergic agonists and antagonists exhibit moderate to weak affinities for
this site. The rat choroid plexus 125I-LSD binding site appears to
represent a new type of serotonergic site which is located on non-neuronal
cells in this tissue.
This article has been cited by other articles:
|
|
|
|
 
D. Cussac, A. Newman-Tancredi, D. Duqueyroix, V. Pasteau, and M. J. Millan
Differential Activation of Gq/11 and Gi3 Proteins at 5-Hydroxytryptamine2C Receptors Revealed by Antibody Capture Assays: Influence of Receptor Reserve and Relationship to Agonist-Directed Trafficking
Mol. Pharmacol.,
September 1, 2002;
62(3):
578 - 589.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. R. McMahon and K. A. Cunningham
Antagonism of 5-Hydroxytryptamine2A Receptors Attenuates the Behavioral Effects of Cocaine in Rats
J. Pharmacol. Exp. Ther.,
April 1, 2001;
297(1):
357 - 363.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Chang, L. Zhang, J. P. Tam, and E. Sanders-Bush
Dissecting G Protein-coupled Receptor Signaling Pathways with Membrane-permeable Blocking Peptides. ENDOGENOUS 5-HT2C RECEPTORS IN CHOROID PLEXUS EPITHELIAL CELLS
J. Biol. Chem.,
March 15, 2000;
275(10):
7021 - 7029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Pineyro and P. Blier
Autoregulation of Serotonin Neurons: Role in Antidepressant Drug Action
Pharmacol. Rev.,
September 1, 1999;
51(3):
533 - 591.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Fisone, G. L. Snyder, J. Fryckstedt, M. J. Caplan, A. Aperia, and P. Greengard
Na[IMAGE],K[IMAGE]-ATPase in the Choroid Plexus
J. Biol. Chem.,
February 10, 1995;
270(6):
2427 - 2430.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Luthman, A. Fredriksson, A. Plaznik, and T. Archer
Ketanserin and mianserin treatment reverses hyperactivity in neonatally dopamine-lesioned rats
J Psychopharmacol,
January 1, 1991;
5(4):
418 - 425.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D Julius, T. Livelli, T. Jessell, and R Axel
Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation
Science,
June 2, 1989;
244(4908):
1057 - 1062.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D Julius, A. MacDermott, R Axel, and T. Jessell
Molecular characterization of a functional cDNA encoding the serotonin 1c receptor
Science,
July 29, 1988;
241(4865):
558 - 564.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M.D. Tricklebank
Subtypes of 5-HT receptors
J Psychopharmacol,
January 1, 1987;
1(4):
222 - 226.
[PDF]
|
|
|
|
|
|
|
C. Becamel, A. Figge, S. Poliak, A. Dumuis, E. Peles, J. Bockaert, H. Lubbert, and C. Ullmer
Interaction of Serotonin 5-Hydroxytryptamine Type 2C Receptors with PDZ10 of the Multi-PDZ Domain Protein MUPP1
J. Biol. Chem.,
April 13, 2001;
276(16):
12974 - 12982.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
