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Journal of Neuroscience, Vol 5, 3189-3203, Copyright © 1985 by Society for Neuroscience
Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study
EB De Souza, TR Insel, MH Perrin, J Rivier, WW Vale and MJ Kuhar
Corticotropin-releasing factor (CRF) receptor-binding sites have been
localized and quantified in the rat central nervous system (CNS) by
autoradiography with an iodine-125-labeled analogue of ovine CRF
substituted with norleucine and tyrosine at amino acid residues 21 and 32,
respectively. High affinity and pharmacologically specific receptor-
binding sites for CRF were found in discrete areas within the rat CNS. CRF
receptors were highly concentrated in laminae 1 and 4 throughout the
neocortex, the external plexiform layer of the olfactory bulb, the external
layer of the median eminence, several cranial nerve nuclei in the brainstem
including the facial, oculomotor, trochlear, vestibulocochlear, and
trigeminal nuclei, the deep cerebellar nuclei, and the cerebellar cortex.
Moderate concentrations of CRF receptors were present in the olfactory
tubercle, caudate-putamen, claustrum, nucleus accumbens, nucleus of the
diagonal band, basolateral nucleus of the amygdala, paraventricular nucleus
of the hypothalamus, mammillary peduncle, inferior and superior olives,
medullary reticular formation, inferior colliculus, and brainstem nuclei
including tegmental, parabrachial, hypoglossal, pontine, cuneate, and
gracilis nuclei, and in spinal cord. Lower densities of CRF binding were
found in the bed nucleus of the stria terminalis, central and medial
amygdaloid nuclei, and regions of the thalamus, hypothalamus, hippocampus,
and brainstem. The distribution of CRF-binding sites generally correlates
with the immunocytochemical distribution of CRF pathways and with the
pharmacological sites of action of CRF. These data strongly support a
physiological role for endogenous CRF in regulating and integrating
functions in the CNS.
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