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Journal of Neuroscience, Vol 5, 3278-3294, Copyright © 1985 by Society for Neuroscience
Lactoseries carbohydrates specify subsets of dorsal root ganglion neurons projecting to the superficial dorsal horn of rat spinal cord
J Dodd and TM Jessell
Cell surface carbohydrates are thought to play important roles in the
development and differentiation of mammalian cells. In previous studies we
have found that one population of dorsal root ganglion (DRG) neurons is
specified by the expression of complex globoseries oligosaccharides (Dodd,
J., D. Solter, and T. M. Jessell (1984) Nature 311: 469-472; Jessell, T.
M., and J. Dodd (1985) Philos. Trans. R. Soc. Lond. (Biol.) 308: 271-281).
We now report that monoclonal antibodies (MAbs) directed against backbone
structures of lactoseries oligosaccharides define antigens present in the
cytoplasm of a second, anatomically and functionally distinct subset of DRG
neurons. Lactoseries carbohydrate structures identified by MAb A5 are
restricted to small- and intermediate-diameter DRG neurons with central
projections in the superficial dorsal horn of the rat spinal cord. The
distribution of labeled terminals suggests that many of the DRG neurons
that express lactoseries carbohydrates are likely to convey nociceptive
information. More complex galactose- and fucose-substituted lactoseries
structures recognized by MAbs LD2, KH10, TC6, TD10, LA4, and anti-Lewis a
are segregated on subsets of DRG neurons that differ in their expression of
substance P, somatostatin, and fluoride-resistant acid phosphatase and in
their laminar termination in the superficial dorsal horn. The majority of
lactoseries carbohydrate antigens identified in the cytoplasm of DRG
neurons are also expressed on the surface of subsets of DRG neurons in
culture. These studies establish that structurally defined carbohydrate
differentiation antigens specify the majority of primary sensory neurons
with cutaneous receptive fields. Moreover, lactoseries carbohydrate
structures similar or identical to those expressed on neonatal DRG neurons
in culture have been implicated in cell-cell interactions at early stages
of preimplantation embryonic development. Our observations suggest
strategies for testing the hypothesis that carbohydrates present on the
surface of subsets of DRG neurons play a role in cell interactions that
contribute to the laminar organization of sensory afferents in the
developing spinal cord.
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