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Journal of Neuroscience, Vol 5, 450-458, Copyright © 1985 by Society for Neuroscience
Evidence for differential localization of noradrenaline and neuropeptide Y in neuronal storage vesicles isolated from rat vas deferens
G Fried, L Terenius, T Hokfelt and M Goldstein
Using the technique of homogenization and subsequent density gradient
centrifugation combined with ultrastructural analysis, the subcellular
localization of noradrenaline and neuropeptide Y (NPY) was studied in vas
deferens of castrated male rats. Noradrenaline showed two peaks in the
gradient: one major peak at low density and another at high density. Only
one NPY peak was seen, which coincided with the high density peak of
noradrenaline. Electron microscopic analysis revealed high proportions of
small and large vesicles in the light and heavy fractions, respectively.
The present results indicate a differential subcellular localization of
noradrenaline and NPY in the noradrenergic nerve endings of vas deferens.
Thus, small vesicles seem to contain only noradrenaline, whereas the large
vesicles may contain both noradrenaline and NPY.
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