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Journal of Neuroscience, Vol 5, 673-684, Copyright © 1985 by Society for Neuroscience
Development of the rat superior cervical ganglion: ganglion cell maturation
E Rubin
The development of superior cervical ganglion cells has been studied in the
fetal rat. Sympathetic cells appear first in thoracic sites and, one day
later, in cervical sites; localized proliferation among these cells gives
rise to the superior cervical and stellate ganglia. The maturation of
superior cervical ganglion cells was examined by staining these neurons
with horseradish peroxidase in fetal preparations maintained in vitro. This
method showed that cells begin to extend processes at widely different
times, without regard to a given cell's position in the ganglion.
Postganglionic axons appear as early as day 12 of gestation (E12), when
only a small number of ganglion cells have emerged from the mitotic cycle.
The axon generally originates from a point on the ganglion cell body that
is oriented toward the route of subsequent axon extension. As the
postganglionic axons grow, they do not branch within the superior cervical
ganglion and branch only to a slight extent, if at all, within developing
peripheral nerves. Axonal growth is rapid, and fibers reach relatively
remote sympathetic targets as early as E15. Dendrites first appear on E14
and are elaborated by ganglion cells that have already extended their
axons. By the end of gestation, the number of primary dendrites found on
some cells already falls within the range found in maturity.
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