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Journal of Neuroscience, Vol 5, 1402-1411, Copyright © 1985 by Society for Neuroscience
Nerve growth cones isolated from fetal rat brain. III. Calcium- dependent protein phosphorylation
F Katz, L Ellis and KH Pfenninger
Calcium-dependent protein kinase activities have been studied in nerve
growth cone particles (GCPs) and compared with those of synaptosomes. GCPs
contain a set of phosphoproteins qualitatively similar to that of synaptic
nerve terminals. However, major quantitative differences appear to exist:
whereas synapsin I phosphorylation is relatively weak, the major kinase
substrates of GCPs are a 46,000-dalton membrane protein (calcium/calmodulin
dependent) and two acidic proteins of 80,000 and 40,000 daltons,
phosphorylated by a calcium/phospholipid- dependent protein kinase. The
presence of synaptic kinase activities in GCPs is consistent with their
neuronal origin. The role of these kinases in GCPs is not understood at
present. They may be involved in growth-related functions and/or may
prepare the sprouting neuron for synaptic function.
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