WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Introducing ALZET?ew Model 2006 Pump
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leblanc, G.
Right arrow Articles by Landis, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leblanc, G.
Right arrow Articles by Landis, S.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 6, 260-265, Copyright © 1986 by Society for Neuroscience

ARTICLE

Development of choline acetyltransferase (CAT) in the sympathetic innervation of rat sweat glands

G Leblanc and S Landis

It has been postulated that the developing sympathetic innervation of rat eccrine sweat glands changes from adrenergic to cholinergic under the influence of its target. In agreement with previous evidence that the sympathetic innervation of adult rat sweat glands is cholinergic, we found that choline acetyltransferase (CAT)-immunoreactive nerve fibers are present in adult glands, and that gland-rich chunks of adult footpads contain CAT enzyme activity. We were therefore interested in determining when CAT activity is first expressed in the developing gland innervation. Low levels of acetylating activity were observed in rat footpads as early as postnatal day 4, when sympathetic fibers first contact the glands. A greater than fourfold increase in CAT specific activity occurred between postnatal days 11 and 21. Neonatal treatment of rats with the adrenergic neurotoxin 6-hydroxydopamine (6-OHDA) eliminated most of the CAT activity in 14 and 19 d footpads. In contrast, the acetylating activity observed prior to day 11 was unaffected by neonatal 6-OHDA treatment, and only slightly reduced by the selective CAT inhibitor, naphthylvinylpyridine. These results indicate that the sympathetic fibers that innervate rat sweat glands do not acquire detectable levels of CAT activity until a full week after they contact the glands.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Giordano, C. Kay Song, R. R. Bowers, J. Christopher Ehlen, A. Frontini, S. Cinti, and T. J. Bartness
Reply to Kreier and Buijs: no sympathy for the claim of parasympathetic innervation of white adipose tissue
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R550 - R552.
[Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
A. Giordano, A. Frontini, M. Castellucci, and S. Cinti
Presence and Distribution of Cholinergic Nerves in Rat Mediastinal Brown Adipose Tissue
J. Histochem. Cytochem., July 1, 2004; 52(7): 923 - 930.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Tian, B. Habecker, G. Guidry, A. Gurtan, M. Rios, S. Roffler-Tarlov, and S. C. Landis
Catecholamines Are Required for the Acquisition of Secretory Responsiveness by Sweat Glands
J. Neurosci., October 1, 2000; 20(19): 7362 - 7369.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. E. Asmus, S. Parsons, and S. C. Landis
Developmental Changes in the Transmitter Properties of Sympathetic Neurons That Innervate the Periosteum
J. Neurosci., February 15, 2000; 20(4): 1495 - 1504.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. W. Hoyle, R. M. Graham, J. B. Finkelstein, K.-P. T. Nguyen, D. Gozal, and M. Friedman
Hyperinnervation of the Airways in Transgenic Mice Overexpressing Nerve Growth Factor
Am. J. Respir. Cell Mol. Biol., February 1, 1998; 18(2): 149 - 157.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
B. A. Habecker, A. J. Symes, N. Stahl, N. J. Francis, A. Economides, J. S. Fink, G. D. Yancopoulos, and S. C. Landis
A Sweat Gland-derived Differentiation Activity Acts through Known Cytokine Signaling Pathways
J. Biol. Chem., November 28, 1997; 272(48): 30421 - 30428.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Tsahai Tafari, S. A. Thomas, and R. D. Palmiter
Norepinephrine Facilitates the Development of the Murine Sweat Response But Is Not Essential
J. Neurosci., June 1, 1997; 17(11): 4275 - 4281.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. ElShamy, S Linnarsson, K. Lee, R Jaenisch, and P Ernfors
Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets
Development, January 2, 1996; 122(2): 491 - 500.
[Abstract] [PDF]

Home page
 ScienceHome page
B. Habecker and S. Landis
Noradrenergic regulation of cholinergic differentiation
Science, June 10, 1994; 264(5165): 1602 - 1604.
[Abstract] [PDF]

Home page
 ScienceHome page
K. Lee, K Bachman, S Landis, and R Jaenisch
Dependence on p75 for innervation of some sympathetic targets
Science, March 11, 1994; 263(5152): 1447 - 1449.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M. Rao, P. Patterson, and S. Landis
Multiple cholinergic differentiation factors are present in footpad extracts: comparison with known cholinergic factors
Development, January 11, 1992; 116(3): 731 - 744.
[Abstract] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-