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Journal of Neuroscience, Vol 6, 274-280, Copyright © 1986 by Society for Neuroscience
Electrophysiological evidence for the existence of both D-1 and D-2 dopamine receptors in the rat nucleus accumbens
FJ White and RY Wang
Extracellular single-unit recording and microiontophoretic techniques were
used to characterize the pharmacological properties of dopamine (DA)
receptors within the rat nucleus accumbens (NAc), a forebrain structure
that receives a dense innervation from mesolimbic DA- containing neurons
(A10 DA neurons) located in the ventral tegmental area (VTA). Of the NAc
neurons tested, 75% were inhibited by microiontophoretic administration of
the selective D-2 receptor agonist, LY-141865, whereas 38% were inhibited
by microiontophoretic administration of the selective D-1 receptor agonist,
SKF-38393. Of the 30 NAc neurons that were tested with both of these
agonists, nine were inhibited by both agonists, 11 were inhibited only by
LY-141865, five were inhibited only by SKF-38393, and five were not
affected by either of these compounds. The inhibitory effects of LY-141865
were blocked and reversed by either intravenous or iontophoretic
administration of the selective D-2 antagonist (-)-sulpiride, which,
however, failed to alter the inhibitory effects of SKF-38393. In contrast,
the purportedly selective D-1 antagonist, SCH-23390, selectively blocked
and reversed the inhibitory effects of SKF-38393, suggesting that the two
agonists were producing their inhibitory effects via distinct DA receptors.
Additional experiments indicated that intravenous administration of LY-
141865 caused a biphasic increase/decrease in the activity of NAc neurons.
The initial rate increase was apparently due to disinhibition since it was
also shown that D-2 DA receptors located on A10 DA neurons exhibited a
3-10-fold greater sensitivity to LY-141865 and DA as compared to the NAc
D-2 receptors.(ABSTRACT TRUNCATED AT 250 WORDS)
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