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Journal of Neuroscience, Vol 6, 68-81, Copyright © 1986 by Society for Neuroscience
Reticularis thalami neurons revisited: activity changes during shifts in states of vigilance
M Steriade, L Domich and G Oakson
This study tested the hypothesis that inhibitory actions are exerted by
reticularis thalami (RE) neurons upon thalamocortical neurons. The RE
neurons were recorded in the rostral pole and lateral districts of the
nucleus, and were activated monosynaptically by cortical volleys.
Thalamocortical neurons were identified antidromically in intralaminar and
ventrolateral nuclei. During sleep with EEG synchronization, prolonged
spike barrages of RE neurons extended over the whole spindle sequences.
This result suggests that RE neurons are depolarized throughout spindle
oscillations, whereas thalamocortical neurons show, simultaneously, long
hyperpolarizations and short rebounds. During waking, parallelism rather
than reciprocity was found between RE and thalamocortical neurons.
Spontaneous discharge rates almost doubled in RE neurons on arousal from
sleep, and the probability of cortically evoked short-latency discharges
increased. The increase in spontaneous firing rates of RE neurons during
natural arousal is consistent with their short-latency synaptic excitation
by stimulating the rostral brain stem reticular formation after chronic
degeneration of passing fibers. We suggest that RE cells inhibit GABAergic
local-circuit cells, in addition to inhibiting thalamocortical neurons, and
that different ratios of inhibitory effects are exerted by RE neurons upon
these two cell classes during waking and sleep. We further suggest that,
upon arousal, disinhibition of thalamocortical neurons (via the local-
circuit neurons) outweighs direct inhibition of the thalamocortical
neurons.
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