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Journal of Neuroscience, Vol 6, 2908-2914, Copyright © 1986 by Society for Neuroscience
Alterations in corticotropin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress
PB Chappell, MA Smith, CD Kilts, G Bissette, J Ritchie, C Anderson and CB Nemeroff
Corticotropin releasing factor (CRF) may regulate endocrine, autonomic, and
behavioral responses to stress. Evidence indicates that CRF-like
immunoreactivity (CRF-LI) is widely distributed throughout the CNS. In this
study, the distribution of CRF-LI was determined in 36 rat brain regions by
combined radioimmunoassay-micropunch dissection techniques and the effect
of stress on CRF-LI was investigated, using a chronic stress model that
induces endocrine changes in rats similar to those seen in depressed
humans. A control group of rats was handled daily. An acute stress group
was subjected to 3 hr of immobilization at 4 degrees C, while a chronic
stress group was exposed to unpredictable stressors. Thirty-six brain
regions were microdissected by the technique of Palkovits and assayed for
CRF-LI, using a specific antiserum to ovine CRF. CRF-LI was detected in
most regions. In controls, the highest concentrations were found in the
arcuate nucleus/median eminence, the hypothalamic paraventricular (PVN)
nucleus, and the periventricular nucleus. The next highest levels were
found in the raphe nuclei and dorsal vagal complex. CRF-LI was well
represented in the locus coeruleus (LC); in the central, cortical, and
medial amygdaloid nuclei; and in the bed nucleus of the stria terminalis.
Low concentrations occurred in the hippocampus and cerebrocortical regions.
Appreciable concentrations were detected in midbrain and brain stem
regions. Acute stress reduced CRF-LI in the arcuate nucleus/median eminence
(ME) (by 52%) and in the median preoptic (MPO) nucleus (by 32%) and doubled
its concentration in the locus coeruleus.(ABSTRACT TRUNCATED AT 250 WORDS)
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