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Journal of Neuroscience, Vol 6, 3006-3009, Copyright © 1986 by Society for Neuroscience
Preserved motor learning in Alzheimer's disease: implications for anatomy and behavior
PJ Eslinger and AR Damasio
Learning and retention of 3 types of information were examined in patients
with Alzheimer's disease (AD) and in normal controls. While patients were
unable to learn series of frequent words and unfamiliar faces, they
improved significantly in a motor skill, showing a learning curve similar
to controls. Furthermore, no significant loss of the motor skill was
evident in a 20 min delay trial. Such dissociation in learning has not been
noted previously in AD, although it has been noted in amnesias caused by
other disease processes. The results support the existence of two,
relatively independent, learning systems related to "declarative" knowledge
and "procedural" knowledge. Judging from the pathologic correlates of these
amnesias, the declarative knowledge system appears to be associated with
corticotemporo/limbic structures, while the procedural system is likely to
depend on corticocerebellar/striatal structures. The data also offer
additional cognitive correlates for the selective damage to neural systems
recently identified in AD.
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