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Journal of Neuroscience, Vol 6, 3474-3482, Copyright © 1986 by Society for Neuroscience
Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats
D Verge, G Daval, M Marcinkiewicz, A Patey, S el Mestikawy, H Gozlan and M Hamon
The distribution of the 2 main types (A and B) of 5-HT1 binding sites in
the rat brain was studied by light-microscopic quantitative
autoradiography. The 5-HT1A sites were identified using 3H-8-hydroxy-2-
(N-dipropylamino)tetralin (3H-8-OH-DPAT) or 3H-5-HT as the ligand. In the
latter case, it was shown that 3H-5-HT binding to 5-HT1A sites corresponded
to that displaceable by 0.1 microM 8-OH-DPAT or 1 microM spiperone. The
"non-5-HT1A" sites labeled by 3H-5-HT in the presence of 0.1 microM
8-OH-DPAT corresponded mainly to 5-HT1B sites. 5-HT1A binding was notably
high in limbic regions (dentate gyrus, CA1 and CA3 hippocampal regions,
lateral septum, frontal cortex), whereas 5-HT1B binding was particularly
concentrated in extrapyramidal areas (caudate nucleus, globus pallidus,
substantia nigra). Except in the latter regions, where only one class of
5-HT1 sites was found, both 5-HT1A and 5-HT1B sites existed in all areas
examined. The selective degeneration of serotoninergic neurons produced by
an intracerebral injection of 5,7- dihydroxytryptamine was associated only
with a significant loss of 5- HT1A binding to the dorsal raphe nucleus
(-60%) and of 5-HT1B binding to the substantia nigra (-37%). These results
are discussed in relation to the possible identity of 5-HT1A and/or 5-HT1B
sites with the presynaptic 5-HT autoreceptors controlling nerve impulse
flow and neurotransmitter release in serotoninergic neurons.
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