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Journal of Neuroscience, Vol 6, 3576-3594, Copyright © 1986 by Society for Neuroscience
Distribution of stage-specific neurite-associated proteins in the developing murine nervous system recognized by a monoclonal antibody
M Yamamoto, AM Boyer, JE Crandall, M Edwards and H Tanaka
A monoclonal antibody, 4D7, obtained with embryonic rat brain as an
immunogen, recognizes an epitope on 3 protein species of 150-160, 100- 110,
and 80 kDa, present in mouse and rat brain during the fetal period. Vital
immunostaining of dissociated cultures of fetal forebrain indicates that
the antigen is localized largely on the external plasma membrane of a
subpopulation of neurites. Immunocytochemistry reveals that the
distribution of the antigen in vivo is restricted to the nervous system.
Immunoreactivity is concentrated primarily in the pathways of a limited set
of CNS and PNS axon systems during early stages of their development, as
delineated by staining with the neurofilament antibody, C2. Depending on
the particular axon system, immunoreactivity with 4D7 persists only for one
to several days of prenatal or perinatal development. In the spinal cord,
stage-specific- neurite-associated proteins (SNAP) expression occurs first
along motor axon pathways on embryonic day (E) 10 and then within the nerve
trunks of dorsal root ganglia and the commissural fiber system on E11.
Immunoreactivity is detectable among most cranial nerves starting in the
interval from E11 to E13. Within the brain, the onset of SNAP expression
within several discrete axon tracts occurs in the interval E14-16,
including the lateral olfactory tract, anterior commissure, corpus
callosum, fasciculus retroflexus, and fornix. Immunoreactivity within the
embryonic intermediate zones of some structures matches the location of
certain other axon systems. Sites of 4D7 staining which do not correspond
to the location of axon populations include the internal portion of the
external granular layer of the postnatal cerebellum and the cortex of the
reeler mutant mouse. The predominant localization of the 4D7 antigen among
axon systems and its precisely regulated spatio- temporal pattern of
expression are consistent with the possibility that the SNAP antigens play
a significant role in the early stages of growth of axonal tracts in vivo.
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