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Journal of Neuroscience, Vol 6, 3655-3668, Copyright © 1986 by Society for Neuroscience
The relationship between the geniculocortical afferents and their cortical target cells during development of the cat's primary visual cortex
CJ Shatz and MB Luskin
To study the prenatal development of connections between the lateral
geniculate nucleus (LGN) and the primary visual cortex in the cat, we have
examined the relationship between the position of ingrowing afferents from
the LGN and their target cells in cortical layers 4 and 6 at various times
during the cat's 65 d gestation period and during the first 3 weeks of
postnatal life. In 1 series of experiments, the method of transneuronal
transport of intraocularly injected tritiated proline (3H-proline),
followed by autoradiography, was used to label the developing
geniculocortical pathway. In another series, the tritiated thymidine
(3H-thymidine) method was employed to keep track of the cells destined for
layers 4 and 6 by labeling them on their birthdates (layer 4: embryonic day
(E) 37-43; layer 6: E31-36) (Luskin and Shatz, 1985b) and then charting
their locations at subsequent times during development. The results of the
2 sets of experiments were compared at corresponding ages. By E39, many of
the cells of cortical layer 6 have completed their migrations and are
situated within the cortical plate immediately above the subplate. However,
the transneuronal labeling pattern indicates that the geniculocotical
afferents have not yet arrived within the vicinity of the future visual
cortex, but rather are still en route and confined within the optic
radiations of the telencephalon. By E42, a week after the first afferents
can be detected in the radiations, substantial transneuronal label is found
in the subplate immediately below future visual cortex. However, the
overlying cortical plate is free of label. Over the next 2 weeks,
geniculocortical axons continue to accumulate in the subplate zone, and, in
addition, transneuronal label can be found in the marginal zone. By E55 a
faint geniculocortical projection can be detected within the cortical
plate, but only within its deeper half (future layers 5 and 6), and even
then the major portion of the projection is still confined to the subplate.
The absence of a projection to cortical layer 4 at these ages is remarkable
in view of the results from our 3H-thymidine experiments, which indicate
that by E57 the majority of cells destined to belong to layer 4 have
already completed their migrations and assumed positions superficial to the
cells of layers 5 and 6. By birth, a substantial geniculocortical
projection to cortical layer 4 can be detected in the transneuronal
autoradiographs.(ABSTRACT TRUNCATED AT 400 WORDS)
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