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Journal of Neuroscience, Vol 6, 553-562, Copyright © 1986 by Society for Neuroscience
Gain control in the electrosensory system mediated by descending inputs to the electrosensory lateral line lobe
J Bastian
The electrosensory lateral line lobe (ELLL) of weakly electric fish, the
primary electrosensory processing station, receives a large descending
input from the midbrain in addition to the input from the electroreceptor
afferents. The role of a major component of this descending input in
determining the properties of ELLL output neurons was investigated. The
descending input was reduced or eliminated by microinjections of the local
anesthetic lidocaine or by small lesions. This treatment increased the
responses of the ELLL output neurons to suprathreshold stimuli by about
300% and also increased the size of the neurons' receptive fields for
moving electrolocation targets and the resolution with which they encode
target distance. The neurons' threshold sensitivity and tuning to amplitude
modulation frequency were unchanged by removal of the descending input. The
results of this study show that this portion of the descending input to the
ELLL normally mediates an inhibition that controls the responsiveness of
ELLL output neurons. This descending input could function as a gain control
mechanism, allowing the animal to modulate the sensitivity of the
electrosensory system in response to changing environmental conditions.
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