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Journal of Neuroscience, Vol 6, 563-571, Copyright © 1986 by Society for Neuroscience
Long-term enhancement of hippocampal synaptic transmission and the acquisition of spatial information
BL McNaughton, CA Barnes, G Rao, J Baldwin and M Rasmussen
The hypothesis that memories are stored as a specific distribution of
strengths in a population of modifiable synapses was examined by the
bilateral induction of long-term enhancement in synapses of the main
afferent fiber system to the hippocampal formation in rats. Brief, high-
frequency activation of the perforant pathway in chronically prepared
animals resulted in a persistent increase in the field EPSP and population
spike, measured extracellularly in fascia dentata. This treatment resulted
in a profound and persistent deficit in the acquisition of new spatial
information in a task requiring spatial "reference" memory, and disruption
of recently acquired spatial information. Well-established spatial memory
was completely unaffected, however, as was the acquisition of spatial
information into short-term "working" memory. These results support the
hypothesis that, during the formation of "cognitive maps," spatial
information must be temporarily stored at modifiable synapses at the input
stage to the hippocampal formation, but that this information is not needed
once the representation of the environment is well established. Spatial
working memory, in a familiar environment, appears not to depend on the
distribution of synaptic strengths in this system at all.
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