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Journal of Neuroscience, Vol 6, 759-763, Copyright © 1986 by Society for Neuroscience
Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization
SG Rayport and S Schacher
The gill withdrawal reflex of the marine mollusk, Aplysia californica,
shows habituation and sensitization, two simple forms of learning. In order
to extend the cellular studies on synaptic plasticity underlying the
changes in the reflex behavior, and to explore further the development of
synaptic plasticity during synapse formation, we have sought to establish
the neural circuit of the gill withdrawal reflex in vitro. We report here
the reconstruction of the elementary gill withdrawal circuit in cell
culture and find that the cells show short- term homosynaptic depression
and heterosynaptic facilitation, the cellular mechanisms of habituation and
sensitization, respectively.
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