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Journal of Neuroscience, Vol 6, 983-989, Copyright © 1986 by Society for Neuroscience
Expression and regulation of catecholaminergic traits in primary sensory neurons: relationship to target innervation in vivo
DM Katz and IB Black
Catecholaminergic (CA) phenotypic characteristics have recently been
detected in adult sensory neurons, demonstrating that CA expression in the
periphery extends beyond the sympathoadrenal axis. Consequently, we may now
determine whether common principles underlie CA phenotypic organization in
functionally and embryologically diverse populations of peripheral neurons.
To begin defining sensory transmitter regulation, the present study
examined the relationship of CA expression to sensory target innervation in
cranial nerve ganglion cells of the adult rat. Retrograde labeling combined
with tyrosine hydroxylase (TH) immunocytochemistry indicated that 80-90% of
CA sensory neurons in the glossopharyngeal petrosal ganglion project
peripherally in the carotid sinus nerve (CSN). Most of these cells
innervate a single target, the carotid body, revealing a striking
correlation between CA expression and the pattern of sensory target
innervation. Furthermore, CSN transection resulted in a transient marked
decrease in TH catalytic activity and immunoreactivity within 1 week.
Activities returned to normal by 3 weeks. Thus, axotomy reversibly
decreased sensory TH, reproducing effects observed with central CA neurons
(Ross et al., 1975), but differing in certain aspects from observations
with sympathetic CA neurons (Cheah and Geffen, 1973; Kessler and Black,
1979). To determine whether disruption of axonal transport itself decreased
TH in petrosal neurons, colchicine cuffs were placed around the intact CSN.
Colchicine blockade reproduced the effects of axotomy, suggesting that
deranged transport, and not axonal damage per se, altered TH. Finally, we
studied the role of sensory projections to the CNS by examining petrosal TH
after glossopharyngeal nerve rhizotomy. In contrast to sequelae of
peripheral axotomy, rhizotomy did not alter TH, suggesting that projections
to the periphery predominate in regulation of sensory TH.(ABSTRACT
TRUNCATED AT 250 WORDS)
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