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Journal of Neuroscience, Vol 6, 1284-1301, Copyright © 1986 by Society for Neuroscience
Orientation selectivity of synaptic potentials in neurons of cat primary visual cortex
D Ferster
Neurons of the visual cortex of the cat were penetrated with intracellular
electrodes and postsynaptic potentials evoked by visual stimuli recorded.
By alternately polarizing the cell with steady current injected through the
recording electrode, IPSPs and EPSPs could be recorded and analyzed
independently. Hyperpolarizing current suppressed IPSPs and enhanced EPSPs
by moving the membrane potential toward the IPSP equilibrium potential.
Depolarizing the cell toward the EPSP equilibrium potential enhanced IPSP.
The responses to electrical stimulation of the LGN, where EPSPs and IPSPs
could be distinguished easily by virtue of their characteristic latencies
and shapes, were used to set the current injection to the appropriate level
to view the two types of synaptic potential. EPSPs were found to be well
oriented in that maximal depolarizing responses could be evoked at only one
stimulus orientation; rotating the stimulus orientation in either direction
produced a fall in the EPSP response. IPSPs were also well tuned to
orientation, and invariably the preferred orientations of EPSPs and IPSPs
in any one cell were identical. In addition, no systematic difference in
the width of tuning of the two types of potential was seen. This result has
been obtained from penetrations of over 30 cortical cells, including those
with simple and complex receptive fields. It is concluded that orientation
of cortical receptive fields is neither created nor sharpened by inhibition
between neurons with different orientation preference. The function of
inhibition evoked simultaneously with excitation by optimally oriented
stimuli has yet to be determined, though it is likely to be the mechanism
underlying other cortical receptive field properties, such as direction
selectivity and end-stopping.
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|
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|
|
|
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|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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4(1):
45 - 52.
[Abstract]
[PDF]
|
|
|
|
|
|
|
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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August 5, 1994;
265(5173):
774 - 777.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M.P. Stryker, B. Chapman, K.D. Miller, and K.R. Zahs
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January 1, 1990;
55(0):
515 - 527.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. Sejnowski, C Koch, and P. Churchland
Computational neuroscience
Science,
September 9, 1988;
241(4871):
1299 - 1306.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. M Martinez, J.-M. Alonso, R C. Reid, and J. A Hirsch
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J. Physiol.,
April 1, 2002;
540(1):
321 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
