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Journal of Neuroscience, Vol 6, 1897-1904, Copyright © 1986 by Society for Neuroscience
The response of chick sensory neurons to brain-derived neurotrophic factor
AM Davies, H Thoenen and YA Barde
To determine the spectrum of activity of brain-derived neurotrophic factor
(BDNF) among first-order sensory neurons, explants of the nine distinct
populations of sensory neurons from embryonic chicks of 3-14 d incubation
(E3-E14) were grown in collagen gels with and without BDNF in the culture
medium. The explants responded to BDNF with profuse neurite outgrowth and
comprised those in which neurons are derived from neural crest (the
dorsomedial part of the trigeminal ganglion, rostromedial part of the
trigeminal mesencephalic nucleus, jugular ganglion, and lumbosacral dorsal
root ganglia) and from epibranchial placodes (the ventrolateral part of the
trigeminal ganglion and the geniculate, petrosal, and nodose ganglia). This
response was first clearly observed in the ventrolateral trigeminal and
nodose ganglia as early as E4, but did not appear until later in other
explants. The dorsomedial trigeminal, jugular, and geniculate ganglia were
the latest to develop a response, which was not apparent until E8. In all
explants the response was maximal between E10 and E12, and there was a
decline in the magnitude of the response from E12 to E14. Although explants
of the vestibular ganglion failed to respond to BDNF, the survival and
growth of vestibular neurons in dissociated neuron-enriched cultures were
promoted by BDNF. To investigate whether all first-order sensory neurons
respond to BDNF or whether BDNF-responsive neurons comprise a distinct
subset, we studied the influence of BDNF and NGF on the survival and growth
of the placode-derived and the neural crest-derived neurons of the
trigeminal ganglion in dissociated neuron-enriched culture.(ABSTRACT
TRUNCATED AT 250 WORDS)
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