 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 6, 2134-2145, Copyright © 1986 by Society for Neuroscience
Morphology and electrophysiological properties of reticularis thalami neurons in cat: in vivo study of a thalamic pacemaker
C Mulle, A Madariaga and M Deschenes
Reticularis thalami neurons (RE neurons) were identified morphologically,
and their electrophysiological properties were studied in cat under
barbiturate anesthesia. Intracellular HRP injections showed that RE neurons
possessed very long dendrites bearing numerous filopodia-like appendages
and that their axons were directed toward main thalamic nuclei. As a rule,
small axonal branches were also emitted within the RE nucleus itself. At
rest, the membrane potential of RE neurons displayed 2 types of
oscillations: a slow 0.1-0.2 Hz oscillation and fast 7-12 Hz oscillations
occurring on the positive phase of the former. Episodes of spindle (7-12
Hz) waves lasted for 2-3 sec and were characterized by rhythmic
depolarizations and burst discharges. Intracellular injections of QX314 and
current pulse analyses revealed the presence in RE cells of 2 distinct
inward currents: a persistent current that promoted tonic firing and a low-
threshold current deinactivated by hyperpolarization that generated burst
discharges. The low-threshold current deinactivated with large somatic
hyperpolarizations (up to 30 mV) and produced depolarizing responses that
lasted for about 70 msec. In addition, low-threshold responses appeared
rhythmically at intervals of about 150 msec after recovery of the membrane
potential from hyperpolarization. Because of their duration, voltage
dependence, and persistence after intracellular injections of QX314, it is
suggested that these responses resulted from activation of a low-threshold
Ca2+ current at the dendritic level. In QX314-injected cells, selective
components of spontaneous oscillations were abolished, among them the
positive phase of the slow oscillation and late depolarizing humps that
followed burst discharges within spindle sequences. However, the rhythmic
occurrence of spindle episodes at 0.1-0.2 Hz was never affected by DC
currents or by QX314 or Cl- injections, suggesting that oscillations within
a particular RE neuron partly reflected the oscillatory behavior of a
network of cells. On the basis of these electrophysiological results and
the known morphological and neurochemical features, a new hypothesis is
proposed to account for the rhythmicity of RE neurons.
This article has been cited by other articles:
|
|
|
|
 
S.-H. Lee, G. Govindaiah, and C. L. Cox
Heterogeneity of firing properties among rat thalamic reticular nucleus neurons
J. Physiol.,
July 1, 2007;
582(1):
195 - 208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Pinault, A. Slezia, and L. Acsady
Corticothalamic 5-9 Hz oscillations are more pro-epileptogenic than sleep spindles in rats
J. Physiol.,
July 1, 2006;
574(1):
209 - 227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Rateau and N. Ropert
Expression of a Functional Hyperpolarization-Activated Current (Ih) in the Mouse Nucleus Reticularis Thalami
J Neurophysiol,
May 1, 2006;
95(5):
3073 - 3085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-Q. Yu, Y. Xiong, Y.-S. Chan, and J. He
In vivo intracellular responses of the medial geniculate neurones to acoustic stimuli in anaesthetized guinea pigs
J. Physiol.,
October 1, 2004;
560(1):
191 - 205.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. DESTEXHE and T. J. SEJNOWSKI
Interactions Between Membrane Conductances Underlying Thalamocortical Slow-Wave Oscillations
Physiol Rev,
October 1, 2003;
83(4):
1401 - 1453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. He
Slow Oscillation in Non-Lemniscal Auditory Thalamus
J. Neurosci.,
September 10, 2003;
23(23):
8281 - 8290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Slaght, N. Leresche, J.-M. Deniau, V. Crunelli, and S. Charpier
Activity of Thalamic Reticular Neurons during Spontaneous Genetically Determined Spike and Wave Discharges
J. Neurosci.,
March 15, 2002;
22(6):
2323 - 2334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Grenier, I. Timofeev, and M. Steriade
Leading role of thalamic over cortical neurons during postinhibitory rebound excitation
PNAS,
November 10, 1998;
95(23):
13929 - 13934.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Kim and D. A. Mccormick
Functional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro
J Neurophysiol,
September 1, 1998;
80(3):
1222 - 1235.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Timofeev, F. Grenier, and M. Steriade
Spike-Wave Complexes and Fast Components of Cortically Generated Seizures. IV. Paroxysmal Fast Runs in Cortical and Thalamic Neurons
J Neurophysiol,
September 1, 1998;
80(3):
1495 - 1513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Debarbieux, J. Brunton, and S. Charpak
Effect of Bicuculline on Thalamic Activity: A Direct Blockade of IAHP in Reticularis Neurons
J Neurophysiol,
June 1, 1998;
79(6):
2911 - 2918.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. S. Sohal, C. L. Cox, and J. R. Huguenard
Localization of CCK Receptors in Thalamic Reticular Neurons: A Modeling Study
J Neurophysiol,
May 1, 1998;
79(5):
2820 - 2824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Destexhe, D. Contreras, and M. Steriade
Mechanisms Underlying the Synchronizing Action of Corticothalamic Feedback Through Inhibition of Thalamic Relay Cells
J Neurophysiol,
February 1, 1998;
79(2):
999 - 1016.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. V. Sanchez-Vives, T. Bal, and D. A. McCormick
Inhibitory Interactions between Perigeniculate GABAergic Neurons
J. Neurosci.,
November 15, 1997;
17(22):
8894 - 8908.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Ulrich and J. R. Huguenard
GABAA-Receptor-Mediated Rebound Burst Firing and Burst Shunting in Thalamus
J Neurophysiol,
September 1, 1997;
78(3):
1748 - 1751.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Pinault, Y. Smith, and M. Deschenes
Dendrodendritic and Axoaxonic Synapses in the Thalamic Reticular Nucleus of the Adult Rat
J. Neurosci.,
May 1, 1997;
17(9):
3215 - 3233.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Cox, J. R. Huguenard, and D. A. Prince
Peptidergic Modulation of Intrathalamic Circuit Activity In Vitro: Actions of Cholecystokinin
J. Neurosci.,
January 1, 1997;
17(1):
70 - 82.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Ulrich and J. R. Huguenard
gamma -Aminobutyric acid type B receptor-dependent burst-firing in thalamic neurons: A dynamic clamp study
PNAS,
November 12, 1996;
93(23):
13245 - 13249.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. V. Sanchez-Vives, T. Bal, U. Kim, M. von Krosigk, and D. A. McCormick
Are the Interlaminar Zones of the Ferret Dorsal Lateral Geniculate Nucleus Actually Part of the Perigeniculate Nucleus?
J. Neurosci.,
October 1, 1996;
16(19):
5923 - 5941.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Traub, R Miles, and R. Wong
Model of the origin of rhythmic population oscillations in the hippocampal slice
Science,
March 10, 1989;
243(4896):
1319 - 1325.
[Abstract]
[PDF]
|
|
|
|
