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Journal of Neuroscience, Vol 6, 2155-2162, Copyright © 1986 by Society for Neuroscience
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
F Hefti
Several findings obtained in recent years suggest that NGF, aside from its
well-established function as a neurotrophic factor for peripheral
sympathetic and sensory neurons, also has trophic influence on the
cholinergic neurons of the basal forebrain. The present study assessed
whether NGF was able to affect survival of central cholinergic neurons
after axonal transections in adult rats. The septo-hippocampal pathway was
transected unilaterally by cutting the fimbria, and animals were implanted
with a cannula through which NGF or control solutions were injected
intraventricularly over 4 weeks. The lesions reduced the number of large
cell bodies, as visualized by Nissl staining in the medial septal nucleus
and in the vertical limb of the diagonal band of Broca. Furthermore, in the
same nuclei, they reduced the number of cell bodies positively stained for
AChE after pretreatment with diisopropylfluorophosphate (a method known to
result in reliable identification of cholinergic neurons in the septal
area). On lesioned sides, the number of cholinergic cells in medial septal
nucleus and the vertical limb of the diagonal band was reduced by 50 +/-
4%, as compared to the number on contralateral sides. On lesioned sides of
animals chronically treated with NGF, the number of AChE-positive cells in
these areas was reduced only by 12 +/- 6%, as compared to control levels.
These findings suggest that fimbrial transections resulted in retrograde
degeneration of cholinergic septo-hippocampal neurons and that NGF
treatment strongly attenuated this lesion-induced degeneration.(ABSTRACT
TRUNCATED AT 250 WORDS)
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