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Journal of Neuroscience, Vol 6, 2267-2277, Copyright © 1986 by Society for Neuroscience
Identified motoneurons and their innervation of axial muscles in the zebrafish
M Westerfield, JV McMurray and JS Eisen
The organization of spinal cord motoneurons and their innervation of axial
(white) muscles in the zebrafish were studied. Motoneurons can be divided
into 2 classes, primary and secondary, on the basis of their cell-body
sizes and positions. Each side of each spinal segment contains 3 primary
motoneurons that are uniquely identifiable as individuals by their
stereotyped cell-body positions and peripheral branching patterns.
Moreover, these motoneurons precisely innervate cell-specific subsets of
contiguous muscle fibers in mutually exclusive regions of their own body
segment. Individual muscle fibers receive inputs from a single primary
motoneuron and, in addition, from up to 3 secondary motoneurons. The
results demonstrate that the precision of innervation previously described
in invertebrates is also present in some vertebrates.
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[PDF]
|
|
|
|
|
|
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[Full Text]
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|
|
|
|
|
|
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|
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|
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|
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|
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|
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[Full Text]
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|
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[PDF]
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