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Journal of Neuroscience, Vol 6, 2416-2426, Copyright © 1986 by Society for Neuroscience
Sensory function and gating of histaminergic neuron C2 in Aplysia
KR Weiss, HJ Chiel and I Kupfermann
This paper explores the possible sensory function of the identified
histaminergic neuron C2. Mechanical stimulation of a narrow region around
the mouth of the animal (perioral zone) elicits brief depolarizing
potentials in C2. Extracellular recordings from the peripheral axons of C2
indicate that the depolarizing potentials are due to action potentials that
are conveyed from the periphery but do not invade the cell body, since they
fail at a region with a low safety factor within the cerebral ganglion.
These blocked axonal spikes (A- spikes) function as if they were excitatory
synaptic inputs to C2, since the synaptic output of C2 does not occur
unless the A-spikes succeed in evoking full action potentials in the soma
(or an electrically close initial segment) of C2. Furthermore, like
synaptic potentials, the A-spikes exhibit temporal and spatial summation,
and facilitation. C2 receives both tonic and phasic inhibitory synaptic
potentials, which can decrease the summation of A-spikes and thereby alter
the frequency-filtering properties of C2 or block its synaptic output.
Thus, C2 appears to be an unusual proprioceptive afferent that has a high
degree of integrative function and may provide critical gating that is
dependent on a variety of external and internal conditions.
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