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Journal of Neuroscience, Vol 6, 2427-2450, Copyright © 1986 by Society for Neuroscience
An identified histaminergic neuron modulates feeding motor circuitry in Aplysia
HJ Chiel, KR Weiss and I Kupfermann
An identified histaminergic neuron, C2, in the marine mollusk Aplysia is a
complex mechanoafferent which appears to contribute to the maintenance of
food arousal by means of its synaptic connections to the metacerebral cell
(MCC). Because C2 also has extensive synaptic outputs to neurons other than
the MCC, we studied its possible motor functions. We identified several
synaptic followers of C2 and found that some were excitatory motor neurons
for extrinsic muscles of the buccal mass, while others were modulatory
motor neurons that inhibited contractions. In addition, we found that these
neurons and other synaptic followers of C2 received powerful inputs during
feeding motor programs. In order to determine the functional significance
of the synaptic outputs of C2, we studied extrinsic buccal muscles (E4 and
E5) whose motor neuron (C6) is excited by C2. Extracellular recordings from
these muscles indicated that they receive input during swallowing and
rejection, but not during biting movements. Lesions of these muscles, or of
all extrinsic muscles, did not prevent animals from feeding, but decreased
feeding efficiency, that is, the amount of seaweed an animal could ingest
with each swallow. The data suggest that C2 is an integrative
proprioceptive cell that functions as a premotor neuron. The non-MCC
synaptic outputs of C2 may reinforce the actions of the central feeding
motor program. Specifically, C2 appears to aid the functioning of muscles
that produce fine adjustments of the buccal mass and contribute to the
efficiency of feeding behavior, rather than in producing gross movements.
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