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Journal of Neuroscience, Vol 7, 3154-3162, Copyright © 1987 by Society for Neuroscience
Single-unit analysis of postnatal olfactory learning: modified olfactory bulb output response patterns to learned attractive odors
DA Wilson, RM Sullivan and M Leon
Department of Psychobiology, University of California, Irvine 92717.
Neonatal rats learn to approach odors associated with stimulation normally
provided by their mother. The present report describes changes in olfactory
bulb single-unit activity following olfactory learning in young rats. Rat
pups were exposed from postnatal day 1 to 18 to either (1)
peppermint-scented air while receiving tactile stimulation (Pepp- Stroked),
(2) peppermint-scented air with no tactile stimulation (Pepp- Only), (3)
clean air and tactile stimulation (Stroked-Only), or (4) clean air and no
tactile stimulation (Naive). On day 19, single-unit activity was recorded
from mitral/tufted cells in urethane- anesthetized, freely breathing pups
in response to either peppermint or a novel orange odor. Mitral/tufted cell
response patterns to peppermint were significantly altered in Pepp-Stroked
animals compared to control pups. Peppermint exposure alone, not associated
with tactile stimulation (Pepp-Only), did not affect subsequent single-cell
response patterns to that odor. In addition, the modification of response
patterns was specific to peppermint and was not associated with a change in
respiration rate. Furthermore, Pepp-Stroked pups had a relative behavioral
preference for peppermint on day 19 compared to control pups. These results
demonstrate that postnatal olfactory learning selectively modifies the
subsequent response patterns of olfactory bulb output cells to the
attractive odor. Furthermore, these results indicate that the initial
coding of an odor's attractive value occurs within the olfactory bulb.
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