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Journal of Neuroscience, Vol 7, 3325-3333, Copyright © 1987 by Society for Neuroscience
Fibronectin-like immunoreactivity in the developing cerebral cortex
GR Stewart and AL Pearlman
Department of Cell Biology, Washington University School of Medicine, St. Louis, Missouri 63110.
In the developing cerebral cortex of the mouse, binding of antibodies
directed against the extracellular matrix glycoprotein fibronectin occurs
with a distinct temporal and spatial pattern. On the 10th embryonic day
(E10), when the wall of the telencephalic vesicle is made up of only the
proliferating cells of the ventricular zone, antifibronectin (aFN) binding
is restricted to the blood vessels and pia-arachnoid. Fibronectin-like
immunoreactivity first appears in the neuropil as small points of
immunofluorescence among the earliest postmitotic neurons that form the
preplate (E11-12). A short time later (E12-13), aFN immunoreactivity
becomes more diffuse but continues to be restricted to the preplate. As
newly arriving neurons form the cortical plate within the preplate
(E13-14), aFN binding is present in the marginal zone above the cortical
plate and in the subplate below it. Both the marginal zone and the subplate
contain early afferents and the cells that were previously part of the
preplate. Binding of aFN is transient; by E18-19 it has diminished to the
point where it is no longer detectable except in the blood vessels and
pia-arachnoid. The transient appearance of fibronectin-like immunostaining
in the zones that contain early cortical afferents suggests that
fibronectin plays a role in forming the migratory pathway for the growth
cones of these axons. In this role it may be acting in concert with other
extracellular matrix components such as hyaluronectin, glycosaminoglycans,
and laminin, which have been shown to have similar spatial
distributions.(ABSTRACT TRUNCATED AT 250 WORDS)
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