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Journal of Neuroscience, Vol 7, 3739-3748, Copyright © 1987 by Society for Neuroscience
Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation
H Rohrer and H Thoenen
Max-Planck-Institute for Psychiatry, Department of Neurochemistry, Martinsried, West Germany.
A population of undifferentiated cells has been characterized during the
early development of nodose and ciliary ganglia. This population is defined
by the absence of surface markers specific for neurons (tetanus toxin
receptor, Q211 antigen) and for glial cells (O4 antigen). These
undifferentiated cell populations were isolated from the ganglia and were
shown to contain neuronal precursor cells that were able to differentiate
in vitro into neurons, as characterized by morphology and surface antigens.
Undifferentiated cells were detected during the period of neuronal birth,
indicating that dividing neuronal precursor cells do not express
neuron-specific surface markers. This was directly shown by
3H-thymidine-labeling studies using nodose ganglia, ciliary ganglia, and
dorsal root ganglia. In sympathetic ganglia, however, no undifferentiated
neuronal precursor cells were detectable at developmental stages when
sympathetic neurons are born. 3H-Thymidine injected during that stage at E7
was incorporated into cells expressing the neuronal markers tetanus toxin
receptor and Q211 antigen. Quantitative fluorimetric determination of the
DNA content of dissociated sympathetic ganglion cells demonstrated the
presence of a population of Q211-positive sympathetic ganglion cells in the
G2 phase of the cell cycle. E7 sympathetic ganglion cells expressing
neuronal surface markers were also shown to be able to divide in vitro. We
have concluded that the relationship between terminal mitosis and the onset
of differentiation differs between ganglia of the chick peripheral nervous
system: Sympathetic ganglion cells continue to divide after the acquisition
of neuronal properties, whereas neuronal precursor cells from other
autonomic and sensory ganglia start to differentiate after a terminal
mitosis.
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