Journal of Neuroscience, Vol 7, 3793-3802, Copyright © 1987 by Society for Neuroscience
Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil
DH Sanes, WA Geary, GF Wooten and EW Rubel
Department of Neuroscience, University of Virginia Medical Center, Charlottesville 22908.
The concentration and relative distribution of glycine receptors were
determined for gerbil brain stem auditory nuclei using 3H-strychnine and
quantitative autoradiographic techniques. Significant binding was observed
in the anteroventral cochlear nucleus, the dorsal cochlear nucleus, the
lateral superior olivary nucleus, and the inferior colliculus. A
non-uniform distribution of binding was seen in 3 of these nuclei, such
that the greatest concentration of glycine receptors was located in the
high-frequency regions. An analysis of neuron soma density suggested that
the amount of post-synaptic membrane could partially explain the
distribution of receptor.